General Structure Information
| PDB ID | 3fxm |
| HGNC Gene Label(s) | PPM1A |
| Structure Name | crystal structure of human protein phosphatase 1a (ppm1a) bound with citrate at 10 mm of mn2+ |
| Resolution | 2.5Å |
| Reference | AUTH T.HU,L.WANG,K.WANG,J.CHEN,H.JIANG,X.SHENTITL STRUCTURAL BASIS FOR THE MN2+-DEPENDENT ACTIVATIONTITL 2 OF HUMAN PPM1AREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 363 |
| Number Of SNVs | 45 |
| Number Of Permutations | 11993 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.223 |
| p-value | 0.489 |
COSMIC
| Number Of Residues | 363 |
| Number Of SNVs | 4 |
| Number Of Permutations | 475 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.667 |
| p-value | 0.599 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 45 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.543 |
| p-value | 0.288 |