4IMN.A | PTGDS

General Structure Information

PDB ID	4imn
HGNC Gene Label(s)	PTGDS
Structure Name	crystal structure of wild type human lipocalin pgds bound with peg mme 2000
Resolution	2.09Å
Reference	AUTH S.M.LIM,D.CHEN,H.TEO,A.ROOS,A.E.JANSSON,T.NYMAN,AUTH 2 L.TRESAUGUES,K.PERVUSHIN,P.NORDLUNDTITL STRUCTURAL AND DYNAMIC INSIGHTS INTO SUBSTRATE BINDING ANDTITL 2 CATALYSIS OF HUMAN LIPOCALIN PROSTAGLANDIN D SYNTHASE.REF J.LIPID RES. V. 54 1630 2013REFN ISSN 0022-2275PMID 23526831DOI 10.1194/JLR.M035410

Variant Set Distributions

ExAC Variants

Number Of Residues	154
Number Of SNVs	41
Number Of Permutations	3184
Optimal Distance Threshold	12.0
K Statistic	0.124
p-value	0.035

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:139872122	rs139945276	Q>L	A:31	(19.81, -12.07, -2.17)
9:139872128	rs371337506	N>S	A:33	(23.32, -17.79, -2.83)
9:139873455	COSM3905906 COSM3905907	R>H	A:42	(9.22, -11.07, -19.21)
9:139873479		S>C	A:50	(13.34, 8.82, -5.31)
9:139873482		N>T	A:51	(15.88, 11.64, -3.70)
9:139873484		S>T	A:52	(14.20, 12.66, -7.75)
9:139873496		R>W	A:56	(9.16, 10.98, -7.64)
9:139873503		K>M	A:58	(8.68, 11.45, -16.58)
9:139873509		A>V	A:60	(4.60, 8.05, -13.59)
9:139873520		M>L	A:64	(4.51, -0.92, -15.94)
9:139873521	rs372967666	M>K	A:64	(4.51, -0.92, -15.94)
9:139873522	rs144270222	M>I	A:64	(4.51, -0.92, -15.94)
9:139873563		N>S	A:78	(22.80, -5.79, -20.46)
9:139873565	rs532268505 COSM1187861	L>V	A:79	(18.79, -3.33, -17.75)
9:139873577	rs199535360	F>V	A:83	(9.94, 4.27, -23.43)
9:139873581		L>P	A:84	(4.86, 4.09, -25.57)
9:139873583	rs146102143	R>G	A:85	(8.25, 8.72, -26.73)
9:139873679		N>D	A:87	(2.97, 6.06, -32.61)
9:139873691		T>A	A:91	(14.98, 0.63, -26.69)
9:139873692		T>N	A:91	(14.98, 0.63, -26.69)
9:139873694		R>G	A:92	(16.34, 3.69, -24.16)
9:139873700		M>L	A:94	(21.03, 0.23, -18.28)
9:139873715		A>T	A:99	(31.22, -4.48, -7.94)
9:139873719	rs547801821	G>E	A:100	(32.57, -7.60, -6.15)
9:139873724		L>F	A:102	(27.58, -12.09, -6.46)
9:139873742	rs368896812	R>W	A:108	(29.48, 6.56, -15.98)
9:139873743		R>Q	A:108	(29.48, 6.56, -15.98)
9:139874404		G>D	A:113	(28.67, 12.27, -14.56)
9:139874407		S>N	A:114	(27.59, 9.98, -12.65)
9:139874409		T>A	A:115	(28.89, 6.38, -10.91)
9:139874410	rs547370037	T>S	A:115	(28.89, 6.38, -10.91)
9:139874418		V>M	A:118	(22.93, -1.22, -8.58)
9:139874419		V>G	A:118	(22.93, -1.22, -8.58)
9:139874434		T>S	A:123	(15.11, -12.05, -5.29)
9:139874436		D>N	A:124	(11.69, -14.87, -5.64)
9:139874451		A>T	A:129	(12.82, -7.69, -7.17)
9:139874479		G>D	A:138	(29.38, 12.85, -8.72)
9:139874487	COSM3848093 COSM3848094	E>K	A:141	(27.47, 11.60, -4.47)
9:139874496	COSM3952531 COSM3952532	R>C	A:144	(18.09, 7.75, -1.82)
9:139874499		M>L	A:145	(16.13, 4.48, -6.93)
9:139874638	COSM3952533 COSM3952534	R>Q	A:151	(9.69, -12.25, -13.57)
9:139874646		T>A	A:154	(-0.50, -7.92, -12.06)
9:139874647		T>N	A:154	(-0.50, -7.92, -12.06)
9:139874649	rs535375895	P>T	A:155	(1.58, -6.60, -8.83)
9:139874650	rs374596572	P>R	A:155	(1.58, -6.60, -8.83)
9:139874665	rs8192609	K>M	A:160	(1.67, -3.46, -3.93)
9:139874677	rs558159287	T>S	A:164	(5.87, 0.18, 1.12)
9:139874679	rs375649462	A>T	A:165	(8.42, -1.66, 3.67)
9:139874692		A>G	A:169	(13.71, 0.99, 5.54)