General Structure Information
| PDB ID | 1yvl |
| HGNC Gene Label(s) | STAT1 |
| Structure Name | structure of unphosphorylated stat1 |
| Resolution | 3.0Å |
| Reference | AUTH X.MAO,Z.REN,G.N.PARKER,H.SONDERMANN,M.A.PASTORELLO,AUTH 2 W.WANG,J.S.MCMURRAY,B.DEMELER,J.E.DARNELL,X.CHENTITL STRUCTURAL BASES OF UNPHOSPHORYLATED STAT1TITL 2 ASSOCIATION AND RECEPTOR BINDING.REF MOL.CELL V. 17 761 2005REFN ISSN 1097-2765PMID 15780933DOI 10.1016/J.MOLCEL.2005.02.021 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 652 |
| Number Of SNVs | 57 |
| Number Of Permutations | 69116 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.008 |
| p-value | 0.882 |
ClinVar
| Number Of Residues | 652 |
| Number Of SNVs | 13 |
| Number Of Permutations | 19950 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.218 |
| p-value | 0.046 |
COSMIC
| Number Of Residues | 652 |
| Number Of SNVs | 12 |
| Number Of Permutations | 20883 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.47 |
| p-value | 0.053 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 57 |
| Number Of ClinVar SNVs | 13 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.149 |
| p-value | 0.013 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 57 |
| Number Of COSMIC SNVs | 9 |
| Optimal Distance Threshold | 38.0 |
| K Statistic | 0.316 |
| p-value | 0.141 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
