General Structure Information
| PDB ID | 3be2 |
| HGNC Gene Label(s) | KDR |
| Structure Name | crystal structure of the vegfr2 kinase domain in complex with a benzamide inhibitor |
| Resolution | 1.75Å |
| Reference | AUTH J.C.HARMANGE,M.M.WEISS,J.GERMAIN,A.J.POLVERINO,AUTH 2 G.BORG,J.BREADY,D.CHEN,D.CHOQUETTE,A.COXON,AUTH 3 T.DEMELFI,L.DIPIETRO,N.DOERR,J.ESTRADA,J.FLYNN,AUTH 4 R.F.GRACEFFA,S.P.HARRIMAN,S.KAUFMAN,D.S.LA,A.LONG,AUTH 5 M.W.MARTIN,S.NEERVANNAN,V.F.PATEL,M.POTASHMAN,AUTH 6 K.REGAL,P.M.ROVETO,M.L.SCHRAG,C.STARNES,A.TASKER,AUTH 7 Y.TEFFERA,L.WANG,R.D.WHITE,D.A.WHITTINGTON,R.ZANONTITL NAPHTHAMIDES AS NOVEL AND POTENT VASCULARTITL 2 ENDOTHELIAL GROWTH FACTOR RECEPTOR TYROSINE KINASETITL 3 INHIBITORS: DESIGN, SYNTHESIS, AND EVALUATION.REF J.MED.CHEM. V. 51 1649 2008REFN ISSN 0022-2623PMID 18324761DOI 10.1021/JM701097Z |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 285 |
| Number Of SNVs | 51 |
| Number Of Permutations | 25101 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.16 |
| p-value | 0.0 |
COSMIC
| Number Of Residues | 285 |
| Number Of SNVs | 9 |
| Number Of Permutations | 958 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.028 |
| p-value | 0.556 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 51 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.376 |
| p-value | 0.051 |