General Structure Information
| PDB ID | 3rze |
| HGNC Gene Label(s) | HRH1 |
| Structure Name | structure of the human histamine h1 receptor in complex with doxepin |
| Resolution | 3.1Å |
| Reference | AUTH T.SHIMAMURA,M.SHIROISHI,S.WEYAND,H.TSUJIMOTO,G.WINTER,AUTH 2 V.KATRITCH,R.ABAGYAN,V.CHEREZOV,W.LIU,G.W.HAN,T.KOBAYASHI,AUTH 3 R.C.STEVENS,S.IWATATITL STRUCTURE OF THE HUMAN HISTAMINE H1 RECEPTOR COMPLEX WITHTITL 2 DOXEPIN.REF NATURE V. 475 65 2011REFN ISSN 0028-0836PMID 21697825DOI 10.1038/NATURE10236 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 268 |
| Number Of SNVs | 65 |
| Number Of Permutations | 33965 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.05 |
| p-value | 0.866 |
COSMIC
| Number Of Residues | 268 |
| Number Of SNVs | 5 |
| Number Of Permutations | 595 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.3 |
| p-value | 0.035 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 65 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.24 |
| p-value | 0.163 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
