General Structure Information
| PDB ID | 1gh7 |
| HGNC Gene Label(s) | CSF2RB |
| Structure Name | crystal structure of the complete extracellular domain of the beta- common receptor of il-3, il-5, and gm-csf |
| Resolution | 3.0Å |
| Reference | AUTH P.D.CARR,S.E.GUSTIN,A.P.CHURCH,J.M.MURPHY,S.C.FORD,D.A.MANN,AUTH 2 D.M.WOLTRING,I.WALKER,D.L.OLLIS,I.G.YOUNGTITL STRUCTURE OF THE COMPLETE EXTRACELLULAR DOMAIN OF THE COMMONTITL 2 BETA SUBUNIT OF THE HUMAN GM-CSF, IL-3, AND IL-5 RECEPTORSTITL 3 REVEALS A NOVEL DIMER CONFIGURATION.REF CELL(CAMBRIDGE,MASS.) V. 104 291 2001REFN ISSN 0092-8674PMID 11207369DOI 10.1016/S0092-8674(01)00213-6 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 408 |
| Number Of SNVs | 107 |
| Number Of Permutations | 72004 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.037 |
| p-value | 0.561 |
COSMIC
| Number Of Residues | 408 |
| Number Of SNVs | 14 |
| Number Of Permutations | 12061 |
| Optimal Distance Threshold | 50.0 |
| K Statistic | 0.341 |
| p-value | 0.434 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 107 |
| Number Of COSMIC SNVs | 14 |
| Optimal Distance Threshold | 50.0 |
| K Statistic | -0.11 |
| p-value | 0.422 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
