General Structure Information
| PDB ID | 3dzy |
| HGNC Gene Label(s) | PPARG |
| Structure Name | intact ppar gamma – rxr alpha nuclear receptor complex on dna bound with rosiglitazone, 9-cis retinoic acid and ncoa2 peptide |
| Resolution | 3.1Å |
| Reference | AUTH V.CHANDRA,P.HUANG,Y.HAMURO,S.RAGHURAM,Y.WANG,T.P.BURRIS,AUTH 2 F.RASTINEJADTITL STRUCTURE OF THE INTACT PPAR-GAMMA-RXR- NUCLEAR RECEPTORTITL 2 COMPLEX ON DNA.REF NATURE V. 456 350 2008REFN ISSN 0028-0836PMID 19043829DOI 10.1038/NATURE07413 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 354 |
| Number Of SNVs | 53 |
| Number Of Permutations | 37633 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.017 |
| p-value | 0.113 |
ClinVar
| Number Of Residues | 354 |
| Number Of SNVs | 8 |
| Number Of Permutations | 5165 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.214 |
| p-value | 0.052 |
COSMIC
| Number Of Residues | 354 |
| Number Of SNVs | 11 |
| Number Of Permutations | 10712 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.018 |
| p-value | 0.778 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 53 |
| Number Of ClinVar SNVs | 8 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.176 |
| p-value | 0.02 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 53 |
| Number Of COSMIC SNVs | 11 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.097 |
| p-value | 0.61 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
