4MXW.R | LTBR – ASTRID

4MXW.R | LTBR

General Structure Information

PDB ID	4mxw
HGNC Gene Label(s)	LTBR
Structure Name	structure of heterotrimeric lymphotoxin lta1b2 bound to lymphotoxin beta receptor ltbr and anti-lta fab
Resolution	3.6Å
Reference	AUTH J.SUDHAMSU,J.YIN,E.Y.CHIANG,M.A.STAROVASNIK,J.L.GROGAN,AUTH 2 S.G.HYMOWITZTITL DIMERIZATION OF LT BETA R BY LT ALPHA 1 BETA 2 IS NECESSARYTITL 2 AND SUFFICIENT FOR SIGNAL TRANSDUCTION.REF PROC.NATL.ACAD.SCI.USA V. 110 19896 2013REFN ISSN 0027-8424PMID 24248355DOI 10.1073/PNAS.1310838110

Variant Set Distributions

ExAC Variants

Number Of Residues	149
Number Of SNVs	29
Number Of Permutations	9711
Optimal Distance Threshold	11.0
K Statistic	0.089
p-value	0.524

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
12:6493797		E>A	R:47	(-28.03, -24.04, -259.92)
12:6493814		P>A	R:53	(-10.27, -29.26, -255.75)
12:6493815		P>L	R:53	(-10.27, -29.26, -255.75)
12:6493817	rs147291553	Q>E	R:54	(-9.00, -33.87, -255.12)
12:6493838		R>C	R:61	(-24.07, -29.30, -257.13)
12:6494215	COSM942521	R>H	R:74	(-9.69, -36.74, -264.90)
12:6494220	rs541860843	R>W	R:76	(-16.71, -41.40, -260.98)
12:6494238		T>P	R:82	(-31.01, -41.63, -251.09)
12:6494251		N>S	R:86	(-35.66, -37.73, -239.90)
12:6494274		Y>H	R:94	(-20.30, -29.99, -252.84)
12:6494280	rs575539111	T>A	R:96	(-20.54, -35.47, -247.53)
12:6494281		T>I	R:96	(-20.54, -35.47, -247.53)
12:6494293		L>R	R:100	(-32.21, -33.62, -238.58)
12:6494422		T>S	R:117	(-39.54, -35.86, -247.02)
12:6494426	rs200343421	S>N	R:118	(-35.81, -36.58, -248.83)
12:6494431		R>W	R:120	(-39.93, -30.66, -250.27)
12:6494432		R>Q	R:120	(-39.93, -30.66, -250.27)
12:6494494		H>Y	R:141	(-47.08, -12.64, -235.63)
12:6494496		H>Q	R:141	(-47.08, -12.64, -235.63)
12:6494510	rs41393248	S>F	R:146	(-51.79, -8.68, -231.63)
12:6494519	COSM3671163	P>L	R:149	(-56.32, 0.40, -232.76)
12:6495240		G>W	R:161	(-49.83, -14.45, -241.24)
12:6495241		G>V	R:161	(-49.83, -14.45, -241.24)
12:6495247	rs149981490	G>D	R:163	(-45.94, -9.50, -241.33)
12:6495255		H>N	R:166	(-49.12, -3.41, -240.59)
12:6495261	rs145130663	V>I	R:168	(-55.43, 0.76, -242.05)
12:6495277		G>V	R:173	(-68.27, 4.20, -243.57)
12:6495291		T>A	R:178	(-63.22, -2.55, -230.12)
12:6495306		A>T	R:183	(-60.57, -6.96, -236.16)
12:6495309		R>S	R:184	(-63.31, -8.37, -239.47)
12:6495310	rs199917609	R>H	R:184	(-63.31, -8.37, -239.47)
12:6495527	rs557684034	G>D	R:195	(-86.71, 4.13, -239.96)
12:6495554		A>V	R:204	(-63.98, 5.15, -236.61)
12:6495564		D>E	R:207	(-72.59, 3.62, -235.64)
12:6495568	COSM1128498	T>A	R:209	(-76.14, 7.99, -233.89)

4MXW.R | LTBR.

4MXW.R | LTBR

General Structure Information

Variant Set Distributions

Mapped Variants

[+] ExAC Missense Variants