General Structure Information
| PDB ID | 3gdq |
| HGNC Gene Label(s) | HSPA1L |
| Structure Name | crystal structure of the human 70kda heat shock protein 1-like atpase domain in complex with adp and inorganic phosphate |
| Resolution | 1.8Å |
| Reference | AUTH M.WISNIEWSKA,T.KARLBERG,L.LEHTIO,I.JOHANSSON,T.KOTENYOVA,AUTH 2 M.MOCHE,H.SCHULERTITL CRYSTAL STRUCTURES OF THE ATPASE DOMAINS OF FOUR HUMAN HSP70TITL 2 ISOFORMS: HSPA1L/HSP70-HOM, HSPA2/HSP70-2, HSPA6/HSP70B,TITL 3 AND HSPA5/BIP/GRP78REF PLOS ONE V. 5 E8625 2010REFN ESSN 1932-6203PMID 20072699DOI 10.1371/JOURNAL.PONE.0008625 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 376 |
| Number Of SNVs | 100 |
| Number Of Permutations | 46982 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.012 |
| p-value | 0.961 |
COSMIC
| Number Of Residues | 376 |
| Number Of SNVs | 9 |
| Number Of Permutations | 5998 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.139 |
| p-value | 0.326 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 100 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | 0.245 |
| p-value | 0.676 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
