General Structure Information
| PDB ID | 2lly |
| HGNC Gene Label(s) | CHRNA4 |
| Structure Name | nmr structures of the transmembrane domains of the nachr a4 subunit |
| Resolution | -1.0Å |
| Reference | AUTH V.BONDARENKO,D.MOWREY,T.TILLMAN,T.CUI,L.T.LIU,Y.XU,P.TANGTITL NMR STRUCTURES OF THE TRANSMEMBRANE DOMAINS OF THE A4B2TITL 2 NACHR.REF BIOCHIM.BIOPHYS.ACTA V.1818 1261 2012REFN ISSN 0006-3002PMID 22361591DOI 10.1016/J.BBAMEM.2012.02.008 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 134 |
| Number Of SNVs | 43 |
| Number Of Permutations | 23176 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.054 |
| p-value | 0.112 |
ClinVar
| Number Of Residues | 134 |
| Number Of SNVs | 4 |
| Number Of Permutations | 921 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.167 |
| p-value | 0.637 |
COSMIC
| Number Of Residues | 134 |
| Number Of SNVs | 6 |
| Number Of Permutations | 3329 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.133 |
| p-value | 0.813 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 43 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.119 |
| p-value | 0.451 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 43 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | -0.253 |
| p-value | 0.7 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
