3VPN.B | RRM2 – ASTRID

3VPN.B | RRM2

General Structure Information

PDB ID	3vpn
HGNC Gene Label(s)	RRM2
Structure Name	crystal structure of human ribonucleotide reductase subunit m2 (hrrm2) mutant
Resolution	2.25Å
Reference	AUTH X.CHEN,Z.XU,H.LIU,L.ZHANG,B.CHEN,L.ZHU,C.YANG,W.ZHU,J.SHAOTITL ESSENTIAL ROLE OF E106 IN THE PROTON-COUPLED ELECTRONTITL 2 TRANSFER IN HUMANREF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	285
Number Of SNVs	45
Number Of Permutations	22679
Optimal Distance Threshold	19.0
K Statistic	0.27
p-value	0.541

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:10263538		V>M	B:67	(-57.20, 15.54, 47.45)
2:10263550	rs368258193	P>S	B:71	(-50.78, 20.33, 44.40)
2:10263560		R>K	B:74	(-52.68, 17.39, 42.09)
2:10263569		P>R	B:77	(-48.60, 10.83, 36.10)
2:10263571	rs371772699	R>C	B:78	(-43.84, 12.51, 34.79)
2:10263583		I>V	B:82	(-36.64, 12.37, 38.82)
2:10263592		I>V	B:85	(-36.97, 19.53, 38.93)
2:10263598		Y>H	B:87	(-42.70, 21.59, 43.03)
2:10263601	rs72542791	H>Y	B:88	(-36.86, 24.22, 41.66)
2:10263618		M>I	B:93	(-34.80, 20.84, 51.63)
2:10263881	rs140269701	I>V	B:113	(-16.00, 4.62, 77.99)
2:10263884		Q>E	B:114	(-12.58, 8.10, 80.91)
2:10263896		S>T	B:118	(-16.79, 10.16, 85.64)
2:10263897		S>F	B:118	(-16.79, 10.16, 85.64)
2:10263962		I>L	B:140	(-42.94, 6.46, 66.00)
2:10264848		E>G	B:147	(-47.42, 3.31, 57.36)
2:10264890		F>C	B:161	(-36.77, 15.12, 52.31)
2:10264891		F>L	B:161	(-36.77, 15.12, 52.31)
2:10264892		Y>H	B:162	(-40.98, 12.67, 53.22)
2:10264940	rs369486626	L>F	B:178	(-24.02, 1.94, 68.70)
2:10264958	rs554679879	I>V	B:184	(-25.12, 0.06, 78.94)
2:10267019		A>V	B:196	(-39.15, 2.28, 76.24)
2:10267022	rs148853193	I>T	B:197	(-42.57, 2.34, 73.91)
2:10267028		T>M	B:199	(-40.22, -0.09, 79.94)
2:10267052		A>E	B:207	(-45.53, 7.59, 71.90)
2:10267065		L>F	B:211	(-48.61, 6.10, 67.68)
2:10267066		R>C	B:212	(-52.94, 9.42, 69.68)
2:10267073		I>T	B:214	(-49.86, 7.14, 62.54)
2:10267219		R>C	B:224	(-51.34, 13.86, 59.21)
2:10267220	COSM714950 COSM1148274	R>H	B:224	(-51.34, 13.86, 59.21)
2:10268987		D>N	B:271	(-37.25, 23.29, 58.14)
2:10269002		M>V	B:276	(-44.56, 20.56, 52.38)
2:10269003		M>T	B:276	(-44.56, 20.56, 52.38)
2:10269015		L>Q	B:280	(-50.94, 22.86, 51.89)
2:10269017		V>I	B:281	(-54.52, 25.10, 49.26)
2:10269023		K>Q	B:283	(-53.29, 25.89, 55.18)
2:10269030		S>L	B:285	(-56.75, 26.74, 61.82)
2:10269047	rs375182199	E>Q	B:291	(-55.32, 22.74, 69.79)
2:10269059		N>H	B:295	(-50.83, 19.34, 73.61)
2:10269060		N>S	B:295	(-50.83, 19.34, 73.61)
2:10269063		A>V	B:296	(-46.80, 19.41, 72.79)
2:10269178		T>I	B:305	(-40.27, 18.88, 85.02)
2:10269207		M>V	B:315	(-30.56, 21.75, 83.53)
2:10269222		M>V	B:320	(-35.93, 23.52, 79.76)
2:10269223		M>T	B:320	(-35.93, 23.52, 79.76)
2:10269225		K>E	B:321	(-41.12, 24.77, 81.61)
2:10269235	rs369824768 COSM164107	I>T	B:324	(-39.92, 24.02, 75.24)
2:10269259		M>T	B:332	(-46.40, 28.70, 65.26)
2:10269260	COSM1004617 COSM1590451	M>I	B:332	(-46.40, 28.70, 65.26)
2:10269361	rs373151401	V>I	B:340	(-48.32, 31.27, 71.66)
2:10269367	rs142631876	R>G	B:342	(-45.63, 36.69, 72.46)
2:10269374		E>A	B:344	(-36.54, 35.86, 75.10)