General Structure Information
| PDB ID | 1nt3 |
| HGNC Gene Label(s) | NTF3 |
| Structure Name | human neurotrophin-3 |
| Resolution | 2.4Å |
| Reference | AUTH M.J.BUTTE,P.K.HWANG,W.C.MOBLEY,R.J.FLETTERICKTITL CRYSTAL STRUCTURE OF NEUROTROPHIN-3 HOMODIMER SHOWS DISTINCTTITL 2 REGIONS ARE USED TO BIND ITS RECEPTORS.REF BIOCHEMISTRY V. 37 16846 1998REFN ISSN 0006-2960PMID 9836577DOI 10.1021/BI981254O |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 108 |
| Number Of SNVs | 19 |
| Number Of Permutations | 11857 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.316 |
| p-value | 0.004 |
COSMIC
| Number Of Residues | 108 |
| Number Of SNVs | 4 |
| Number Of Permutations | 91 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.167 |
| p-value | 0.788 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 19 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.243 |
| p-value | 0.727 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
