General Structure Information
| PDB ID | 2hc2 |
| HGNC Gene Label(s) | PTPRB |
| Structure Name | engineered protein tyrosine phosphatase beta catalytic domain |
| Resolution | 1.4Å |
| Reference | AUTH A.G.EVDOKIMOV,M.POKROSS,R.WALTER,M.MEKEL,B.COX,AUTH 2 C.LI,R.BECHARD,F.GENBAUFFE,R.ANDREWS,C.DIVEN,AUTH 3 B.HOWARD,V.RASTOGI,J.GRAY,M.MAIER,K.G.PETERSTITL ENGINEERING THE CATALYTIC DOMAIN OF HUMAN PROTEINTITL 2 TYROSINE PHOSPHATASE BETA FOR STRUCTURE-BASED DRUGTITL 3 DISCOVERY.REF ACTA CRYSTALLOGR.,SECT.D V. 62 1435 2006REFN ISSN 0907-4449PMID 17139078DOI 10.1107/S0907444906037784 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 280 |
| Number Of SNVs | 60 |
| Number Of Permutations | 30684 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.072 |
| p-value | 0.356 |
COSMIC
| Number Of Residues | 280 |
| Number Of SNVs | 6 |
| Number Of Permutations | 749 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.067 |
| p-value | 0.524 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 60 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.162 |
| p-value | 0.65 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
