General Structure Information
| PDB ID | 3ps5 |
| HGNC Gene Label(s) | PTPN6 |
| Structure Name | crystal structure of the full-length human protein tyrosine phosphatase shp-1 |
| Resolution | 3.1Å |
| Reference | AUTH W.WANG,L.LIU,X.SONG,Y.MO,C.KOMMA,H.D.BELLAMY,Z.J.ZHAO,AUTH 2 G.W.ZHOUTITL CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASETITL 2 SHP-1 IN THE OPEN CONFORMATION.REF J.CELL.BIOCHEM. V. 112 2062 2011REFN ISSN 0730-2312PMID 21465528DOI 10.1002/JCB.23125 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 529 |
| Number Of SNVs | 83 |
| Number Of Permutations | 53554 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.311 |
| p-value | 0.087 |
COSMIC
| Number Of Residues | 529 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1474 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.067 |
| p-value | 0.772 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 83 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.053 |
| p-value | 0.808 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
