General Structure Information
| PDB ID | 2r83 |
| HGNC Gene Label(s) | SYT1 |
| Structure Name | crystal structure analysis of human synaptotagmin 1 c2a-c2b |
| Resolution | 2.7Å |
| Reference | AUTH K.L.FUSON,M.MONTES,J.J.ROBERT,R.B.SUTTONTITL STRUCTURE OF HUMAN SYNAPTOTAGMIN 1 C2AB IN THETITL 2 ABSENCE OF CA2+ REVEALS A NOVEL DOMAIN ASSOCIATION.REF BIOCHEMISTRY V. 46 13041 2007REFN ISSN 0006-2960PMID 17956130DOI 10.1021/BI701651K |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 279 |
| Number Of SNVs | 24 |
| Number Of Permutations | 3047 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.326 |
| p-value | 0.347 |
COSMIC
| Number Of Residues | 279 |
| Number Of SNVs | 8 |
| Number Of Permutations | 1916 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.357 |
| p-value | 0.674 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 24 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | -0.227 |
| p-value | 0.225 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
