General Structure Information
| PDB ID | 2×10 |
| HGNC Gene Label(s) | EPHA2 |
| Structure Name | crystal structure of the complete epha2 ectodomain |
| Resolution | 3.0Å |
| Reference | AUTH E.SEIRADAKE,K.HARLOS,G.SUTTON,A.R.ARICESCU,AUTH 2 E.Y.JONESTITL AN EXTRACELLULAR STERIC SEEDING MECHANISM FOR EPH-TITL 2 EPHRIN SIGNALLING PLATFORM ASSEMBLYREF NAT.STRUCT.MOL.BIOL. V. 17 398 2010REFN ISSN 1545-9993PMID 20228801DOI 10.1038/NSMB.1782 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 475 |
| Number Of SNVs | 151 |
| Number Of Permutations | 59310 |
| Optimal Distance Threshold | 53.0 |
| K Statistic | 0.472 |
| p-value | 0.366 |
COSMIC
| Number Of Residues | 475 |
| Number Of SNVs | 7 |
| Number Of Permutations | 10032 |
| Optimal Distance Threshold | 42.0 |
| K Statistic | 0.571 |
| p-value | 0.568 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 151 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 42.0 |
| K Statistic | 0.219 |
| p-value | 0.626 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 1:16477441 | A>S | A:35 | (-34.93, 70.53, 16.68) | |
| 1:16477437 | A>V | A:36 | (-32.81, 71.86, 14.16) | |
| 1:16477438 | A>T | A:36 | (-32.81, 71.86, 14.16) | |
| 1:16477422 | L>P | A:41 | (-39.97, 74.16, 10.38) | |
| 1:16477423 | rs147977279 | L>V | A:41 | (-39.97, 74.16, 10.38) |
| 1:16477404 | P>L | A:47 | (-58.01, 75.32, 14.01) | |
| 1:16477398 | COSM88054 | G>D | A:49 | (-54.90, 79.86, 16.68) |
| 1:16475539 | D>N | A:53 | (-48.84, 77.78, 19.58) | |
| 1:16475451 | R>H | A:82 | (-49.53, 69.59, 7.85) | |
| 1:16475452 | rs190330372 | R>C | A:82 | (-49.53, 69.59, 7.85) |
| 1:16475439 | V>A | A:86 | (-41.53, 64.50, 4.14) | |
| 1:16475418 | R>H | A:93 | (-41.08, 50.41, 8.06) | |
| 1:16475419 | rs200152244 | R>C | A:93 | (-41.08, 50.41, 8.06) |
| 1:16475394 | rs371414588 | T>I | A:101 | (-44.44, 67.21, 28.05) |
| 1:16475388 | R>H | A:103 | (-49.69, 69.80, 33.19) | |
| 1:16475389 | COSM1743260 | R>C | A:103 | (-49.69, 69.80, 33.19) |
| 1:16475379 | N>S | A:106 | (-55.63, 65.85, 38.66) | |
| 1:16475361 | A>V | A:112 | (-62.62, 68.10, 34.33) | |
| 1:16475362 | rs538382189 COSM898865 |
A>T | A:112 | (-62.62, 68.10, 34.33) |
| 1:16475358 | S>T | A:113 | (-63.98, 65.03, 32.51) | |
| 1:16475349 | rs368902486 | K>R | A:116 | (-58.17, 63.40, 27.92) |
| 1:16475331 | Y>C | A:122 | (-53.59, 60.61, 12.68) | |
| 1:16475323 | E>K | A:125 | (-48.69, 58.18, 1.36) | |
| 1:16475319 | S>L | A:126 | (-48.51, 62.37, -1.43) | |
| 1:16475317 | D>H | A:127 | (-47.45, 61.98, -5.51) | |
| 1:16475305 | G>S | A:131 | (-50.30, 72.48, 1.64) | |
| 1:16475286 | R>H | A:137 | (-61.77, 61.75, 4.66) | |
| 1:16475268 | D>A | A:143 | (-51.01, 54.63, 17.95) | |
| 1:16475254 | D>N | A:148 | (-43.63, 57.52, 29.48) | |
| 1:16475242 | V>I | A:152 | (-46.84, 68.60, 38.22) | |
| 1:16475238 | S>N | A:153 | (-46.13, 72.31, 36.64) | |
| 1:16475203 | rs150790360 | V>M | A:165 | (-39.51, 59.10, 24.67) |
| 1:16475194 | rs201078677 | R>C | A:168 | (-44.76, 54.40, 17.85) |
| 1:16475190 | S>F | A:169 | (-43.37, 52.35, 12.58) | |
| 1:16475181 | P>L | A:172 | (-45.21, 49.86, 3.03) | |
| 1:16475179 | rs368346211 | L>F | A:173 | (-43.90, 54.28, 2.52) |
| 1:16475172 | R>H | A:175 | (-47.65, 58.27, -3.04) | |
| 1:16475173 | rs147352564 | R>C | A:175 | (-47.65, 58.27, -3.04) |
| 1:16475162 | F>L | A:178 | (-43.99, 61.39, 4.58) | |
| 1:16475140 | G>S | A:186 | (-57.69, 67.55, 25.51) | |
| 1:16475130 | V>A | A:189 | (-49.22, 68.51, 25.02) | |
| 1:16475127 | A>V | A:190 | (-45.24, 69.43, 24.90) | |
| 1:16475116 | V>I | A:194 | (-40.01, 65.26, 15.62) | |
| 1:16475112 | R>H | A:195 | (-35.68, 61.61, 15.11) | |
| 1:16475113 | rs368758045 | R>C | A:195 | (-35.68, 61.61, 15.11) |
| 1:16475110 | rs375469676 | V>I | A:196 | (-38.42, 60.93, 10.37) |
| 1:16475100 | K>R | A:199 | (-33.40, 51.43, 10.13) | |
| 1:16475096 | rs200541087 | K>N | A:200 | (-29.07, 52.30, 5.17) |
| 1:16475097 | K>T | A:200 | (-29.07, 52.30, 5.17) | |
| 1:16475073 | L>R | A:208 | (-14.69, 36.88, -2.57) | |
| 1:16475050 | rs143736427 | A>T | A:216 | (-34.25, 48.52, 4.93) |
| 1:16475047 | rs200422898 | G>S | A:217 | (-37.04, 46.69, 4.99) |
| 1:16475037 | A>V | A:220 | (-40.28, 40.00, 6.51) | |
| 1:16475001 | rs114498261 | D>G | A:232 | (-10.95, 42.19, -8.99) |
| 1:16474999 | rs200823845 | H>Y | A:233 | (-8.69, 38.77, -10.08) |
| 1:16474995 | A>V | A:234 | (-13.56, 36.63, -8.77) | |
| 1:16474993 | rs370497466 COSM1251271 |
V>M | A:235 | (-15.67, 33.84, -10.25) |
| 1:16474983 | P>R | A:238 | (-19.66, 26.35, -13.18) | |
| 1:16474972 | COSM458455 | E>K | A:242 | (-26.20, 34.26, -7.75) |
| 1:16474965 | R>H | A:244 | (-28.20, 35.50, -3.80) | |
| 1:16474956 | C>Y | A:247 | (-32.00, 44.21, 4.25) | |
| 1:16474948 | rs371097258 | D>N | A:250 | (-32.99, 45.32, 11.98) |
| 1:16474942 | COSM3477577 | E>K | A:252 | (-28.92, 43.82, 10.72) |
| 1:16474923 | G>V | A:258 | (-23.82, 32.23, -2.14) | |
| 1:16474920 | Q>P | A:259 | (-19.30, 31.69, -2.46) | |
| 1:16474903 | G>S | A:265 | (-4.56, 31.47, -10.91) | |
| 1:16474878 | C>F | A:273 | (-7.61, 37.58, -5.28) | |
| 1:16474873 | rs185808210 | A>T | A:275 | (-1.55, 35.42, -8.24) |
| 1:16464919 | rs35484156 | S>L | A:277 | (3.32, 32.04, -7.00) |
| 1:16464920 | S>P | A:277 | (3.32, 32.04, -7.00) | |
| 1:16464913 | COSM352849 COSM1721881 |
G>V | A:279 | (5.41, 27.43, -9.37) |
| 1:16464908 | F>L | A:281 | (-1.11, 24.40, -10.34) | |
| 1:16464905 | K>E | A:282 | (-5.97, 27.60, -8.92) | |
| 1:16464890 | rs201837559 | E>K | A:287 | (-12.69, 26.83, -1.39) |
| 1:16464874 | E>A | A:292 | (3.99, 22.24, -5.80) | |
| 1:16464872 | C>S | A:293 | (4.33, 22.37, -10.01) | |
| 1:16464859 | T>M | A:297 | (6.82, 20.33, -14.64) | |
| 1:16464839 | A>T | A:304 | (-0.70, 29.65, -13.14) | |
| 1:16464825 | E>D | A:308 | (4.68, 23.24, -20.30) | |
| 1:16464827 | COSM3385376 | E>K | A:308 | (4.68, 23.24, -20.30) |
| 1:16464824 | rs201934420 | C>R | A:309 | (5.62, 19.12, -19.32) |
| 1:16464819 | E>D | A:310 | (10.20, 18.19, -18.48) | |
| 1:16464814 | G>A | A:312 | (9.70, 13.92, -22.78) | |
| 1:16464805 | rs139176878 | R>Q | A:315 | (-0.11, 16.51, -19.13) |
| 1:16464806 | R>W | A:315 | (-0.11, 16.51, -19.13) | |
| 1:16464787 | rs372094298 | A>V | A:321 | (-3.41, 19.50, -14.50) |
| 1:16464773 | T>A | A:326 | (3.57, 10.85, -18.30) | |
| 1:16464669 | A>T | A:331 | (8.93, -3.37, -23.28) | |
| 1:16464662 | H>R | A:333 | (11.01, -7.64, -18.11) | |
| 1:16464653 | rs146085387 | T>R | A:336 | (6.87, -16.91, -22.98) |
| 1:16464648 | COSM3802683 | V>M | A:338 | (4.70, -22.94, -24.83) |
| 1:16464630 | rs201230989 | V>M | A:344 | (0.74, -20.90, -28.38) |
| 1:16464627 | rs575151468 | E>K | A:345 | (0.31, -20.42, -24.43) |
| 1:16464623 | L>P | A:346 | (2.01, -15.70, -25.97) | |
| 1:16464620 | R>H | A:347 | (2.10, -17.35, -20.60) | |
| 1:16464621 | R>C | A:347 | (2.10, -17.35, -20.60) | |
| 1:16464614 | rs200490325 | T>M | A:349 | (5.86, -9.30, -17.98) |
| 1:16464615 | T>A | A:349 | (5.86, -9.30, -17.98) | |
| 1:16464612 | rs11543934 | P>T | A:350 | (4.55, -6.03, -16.87) |
| 1:16464597 | rs370923409 | G>R | A:355 | (5.75, 5.85, -17.40) |
| 1:16464590 | R>H | A:357 | (-0.02, 6.53, -17.52) | |
| 1:16464588 | rs201941686 COSM4142964 |
E>K | A:358 | (-1.75, 2.81, -13.76) |
| 1:16464585 | rs368150751 | D>N | A:359 | (-2.97, 3.59, -19.24) |
| 1:16464582 | I>V | A:360 | (-0.39, -0.39, -19.31) | |
| 1:16464570 | rs150248625 | V>I | A:364 | (-0.42, -9.23, -30.72) |
| 1:16464564 | C>G | A:366 | (2.24, -12.47, -36.77) | |
| 1:16464561 | E>K | A:367 | (6.37, -12.60, -38.93) | |
| 1:16464534 | C>R | A:376 | (8.43, -13.87, -44.78) | |
| 1:16464531 | rs373447361 | G>R | A:377 | (5.24, -12.26, -43.23) |
| 1:16464527 | rs201266141 | P>L | A:378 | (2.43, -10.55, -42.46) |
| 1:16464522 | E>K | A:380 | (-3.45, -13.98, -41.92) | |
| 1:16464512 | V>A | A:383 | (-4.09, -17.22, -36.44) | |
| 1:16464509 | R>H | A:384 | (-7.91, -19.68, -34.65) | |
| 1:16464503 | rs141027815 | S>L | A:386 | (-8.10, -16.14, -27.26) |
| 1:16464500 | E>A | A:387 | (-9.25, -13.01, -26.25) | |
| 1:16464495 | rs142009739 | P>S | A:389 | (-5.50, -8.97, -30.83) |
| 1:16464489 | rs34192549 | G>R | A:391 | (-6.24, -4.05, -26.66) |
| 1:16464479 | R>H | A:394 | (-5.68, -11.24, -20.21) | |
| 1:16464480 | R>C | A:394 | (-5.68, -11.24, -20.21) | |
| 1:16464476 | T>I | A:395 | (-0.38, -10.88, -19.37) | |
| 1:16464468 | rs373273453 | T>S | A:398 | (-4.18, -18.80, -26.74) |
| 1:16464453 | COSM424448 | E>K | A:403 | (-0.51, -23.93, -40.61) |
| 1:16464447 | H>Y | A:405 | (7.33, -27.18, -42.09) | |
| 1:16464440 | N>T | A:407 | (9.23, -20.67, -37.93) | |
| 1:16464435 | T>A | A:409 | (7.52, -14.18, -35.42) | |
| 1:16464426 | V>M | A:412 | (4.19, -8.08, -27.73) | |
| 1:16464417 | rs150826389 | R>C | A:415 | (0.63, 1.80, -27.05) |
| 1:16464408 | rs568736295 COSM4024691 |
V>I | A:418 | (1.37, 8.90, -23.87) |
| 1:16464396 | V>L | A:422 | (5.62, 9.11, -29.55) | |
| 1:16464389 | S>N | A:424 | (8.44, 5.01, -30.77) | |
| 1:16464386 | COSM4024690 COSM530217 |
R>H | A:425 | (6.23, 1.66, -31.91) |
| 1:16464378 | rs148381862 | R>C | A:428 | (10.84, -8.51, -25.80) |
| 1:16464371 | A>V | A:430 | (8.65, -14.48, -30.16) | |
| 1:16464363 | S>G | A:433 | (8.63, -24.26, -34.61) | |
| 1:16464351 | rs376978557 | T>S | A:437 | (4.62, -32.47, -39.72) |
| 1:16462259 | P>L | A:440 | (0.11, -39.79, -41.82) | |
| 1:16462254 | V>L | A:442 | (-2.83, -44.89, -44.30) | |
| 1:16462244 | rs144075562 | E>V | A:445 | (-2.46, -49.16, -53.22) |
| 1:16462238 | rs144716232 | R>H | A:447 | (-6.14, -57.16, -50.16) |
| 1:16462239 | R>C | A:447 | (-6.14, -57.16, -50.16) | |
| 1:16462226 | S>L | A:451 | (0.91, -59.57, -49.12) | |
| 1:16462224 | L>I | A:452 | (-0.34, -56.27, -46.89) | |
| 1:16462218 | V>I | A:454 | (0.86, -50.07, -47.49) | |
| 1:16462209 | S>G | A:457 | (-0.05, -39.05, -48.04) | |
| 1:16462199 | COSM294351 | P>L | A:460 | (4.53, -31.39, -50.43) |
| 1:16462196 | P>Q | A:461 | (4.82, -28.57, -47.94) | |
| 1:16462184 | R>Q | A:465 | (10.99, -32.60, -42.16) | |
| 1:16462179 | W>R | A:467 | (15.19, -39.22, -40.01) | |
| 1:16462170 | E>K | A:470 | (8.08, -45.84, -37.61) | |
| 1:16461671 | rs554019648 | S>T | A:481 | (4.41, -58.84, -31.30) |
| 1:16461672 | S>G | A:481 | (4.41, -58.84, -31.30) | |
| 1:16461659 | R>L | A:485 | (9.66, -52.24, -42.87) | |
| 1:16461660 | rs370741075 COSM181791 |
R>C | A:485 | (9.66, -52.24, -42.87) |
| 1:16461657 | rs143490496 | R>C | A:486 | (12.77, -46.66, -39.48) |
| 1:16461654 | rs199586891 | T>P | A:487 | (11.30, -45.83, -45.43) |
| 1:16461650 | E>G | A:488 | (13.48, -42.02, -47.20) | |
| 1:16461651 | rs145459140 | E>K | A:488 | (13.48, -42.02, -47.20) |
| 1:16461647 | rs140392218 | G>V | A:489 | (8.94, -43.69, -48.56) |
| 1:16461639 | rs141123184 | V>M | A:492 | (5.53, -50.56, -48.04) |
| 1:16461627 | rs115171763 | D>N | A:496 | (6.49, -63.09, -45.25) |
| 1:16461618 | COSM1335891 | P>S | A:499 | (-3.70, -66.17, -44.36) |
| 1:16461615 | D>N | A:500 | (-7.86, -65.03, -43.78) | |
| 1:16461588 | A>T | A:509 | (6.42, -38.97, -39.45) | |
| 1:16461581 | rs55747232 | T>M | A:511 | (10.12, -34.78, -37.10) |
| 1:16461578 | Q>R | A:512 | (15.18, -36.14, -36.89) | |
| 1:16461561 | G>S | A:518 | (1.04, -39.95, -36.32) | |
| 1:16461548 | H>R | A:522 | (-5.57, -47.55, -40.72) | |
| 1:16461546 | rs369180720 | E>K | A:523 | (-8.20, -52.23, -39.11) |
| 1:16461536 | T>M | A:526 | (-4.95, -61.18, -45.63) | |
| 1:16461059 | rs548968171 | P>L | A:529 | (-7.34, -69.52, -50.57) |
[+] COSMIC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 1:16475436 | COSM2088740 | Y>C | A:87 | (-39.32, 64.99, -0.71) |
| 1:16475287 | COSM1251272 | R>C | A:137 | (-61.77, 61.75, 4.66) |
| 1:16475256 | COSM393118 | P>L | A:147 | (-47.74, 59.50, 28.95) |
| 1:16475094 | COSM3980014 | C>F | A:201 | (-27.70, 47.97, 5.43) |
| 1:16474932 | COSM4142965 | V>G | A:255 | (-29.99, 34.94, 4.40) |
| 1:16464913 | COSM1721881 | G>E | A:279 | (5.41, 27.43, -9.37) |
| 1:16464648 | COSM3802683 | V>M | A:338 | (4.70, -22.94, -24.83) |