General Structure Information
| PDB ID | 4gj3 |
| HGNC Gene Label(s) | TYK2 |
| Structure Name | tyk2 (jh1) in complex with 2,6-dichloro-4-cyano-n-[2-({[(1r,2r)-2- fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide |
| Resolution | 2.5Å |
| Reference | AUTH J.LIANG,A.VAN ABBEMA,M.BALAZS,K.BARRETT,L.BEREZHKOVSKY,AUTH 2 W.BLAIR,C.CHANG,D.DELAROSA,J.DEVOSS,J.DRISCOLL,C.EIGENBROT,AUTH 3 N.GHILARDI,P.GIBBONS,J.HALLADAY,A.JOHNSON,P.B.KOHLI,Y.LAI,AUTH 4 Y.LIU,J.LYSSIKATOS,P.MANTIK,K.MENGHRAJANI,J.MURRAY,I.PENG,AUTH 5 A.SAMBRONE,S.SHIA,Y.SHIN,J.SMITH,S.SOHN,V.TSUI,M.ULTSCH,AUTH 6 L.C.WU,Y.XIAO,W.YANG,J.YOUNG,B.ZHANG,B.Y.ZHU,S.MAGNUSONTITL LEAD OPTIMIZATION OF A 4-AMINOPYRIDINE BENZAMIDE SCAFFOLD TOTITL 2 IDENTIFY POTENT, SELECTIVE, AND ORALLY BIOAVAILABLE TYK2TITL 3 INHIBITORS.REF J.MED.CHEM. V. 56 4521 2013REFN ISSN 0022-2623PMID 23668484DOI 10.1021/JM400266T |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 287 |
| Number Of SNVs | 62 |
| Number Of Permutations | 11035 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.191 |
| p-value | 0.084 |
COSMIC
| Number Of Residues | 287 |
| Number Of SNVs | 5 |
| Number Of Permutations | 903 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.2 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 62 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.562 |
| p-value | 0.337 |