4ASX.A | ACVR2A

PDB ID	4asx
HGNC Gene Label(s)	ACVR2A
Structure Name	crystal structure of activin receptor type-iia (acvr2a) kinase domain in complex with dihydro-bauerine c
Resolution	2.05Å
Reference	AUTH E.WILLIAMS,A.CHAIKUAD,P.CANNING,P.MAHAJAN,C.D.O.COOPER,AUTH 2 A.BELTRAMI,T.KROJER,K.HUBER,F.BRACHER,F.VON DELFT,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,A.BULLOCKTITL CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE-IIA ( ACVR2A)TITL 2 KINASE DOMAIN IN COMPLEX WITH A BETA- CARBOLINE INHIBITORREF TO BE PUBLISHED

ExAC Variants

COSMIC

ExACCOSMIC

Cosmic vs. ExAC

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:148672836		R>T	A:202	(-31.85, 48.91, 17.79)
2:148672844		C>S	A:205	(-33.13, 39.12, 12.26)
2:148672871	COSM1007182 COSM176082	E>K	A:214	(-48.47, 35.50, 1.09)
2:148672877		V>M	A:216	(-43.75, 36.92, 5.38)
2:148672902		Q>R	A:224	(-30.34, 38.75, 24.48)
2:148674856		K>R	A:226	(-37.81, 38.41, 26.44)
2:148674881		E>D	A:234	(-47.04, 44.69, 24.84)
2:148674951		S>G	A:258	(-36.83, 26.94, 28.08)
2:148674957		D>H	A:260	(-32.86, 26.71, 22.85)
2:148674960	rs562464467	V>M	A:261	(-36.02, 30.59, 23.22)
2:148676071		H>R	A:291	(-47.47, 58.80, -1.71)
2:148676073	COSM1613465	I>V	A:292	(-43.12, 58.75, 0.48)
2:148676087		M>I	A:296	(-43.97, 59.12, 6.76)
2:148676089		A>V	A:297	(-47.05, 61.35, 8.39)
2:148676111		H>Q	A:304	(-47.69, 60.31, 17.71)
2:148676122	COSM441200	P>H	A:308	(-61.11, 57.50, 21.93)
2:148676136		G>C	A:313	(-60.70, 50.49, 22.82)
2:148677805		I>M	A:323	(-38.17, 57.83, 13.73)
2:148677821		L>V	A:329	(-41.07, 50.04, 5.32)
2:148677836	rs149682383	L>M	A:334	(-43.81, 54.45, -3.30)
2:148677881		A>S	A:349	(-51.71, 60.80, 29.87)
2:148677893	COSM1325886	A>T	A:353	(-43.13, 61.75, 35.35)
2:148677911		Q>E	A:359	(-29.23, 58.77, 25.10)
2:148680551		R>W	A:363	(-25.39, 58.66, 18.71)
2:148680632		M>V	A:390	(-40.26, 63.14, 10.49)
2:148680662	COSM441201	R>C	A:400	(-31.64, 60.75, -3.80)
2:148683684	rs377566208	H>L	A:434	(-22.80, 73.09, 21.46)
2:148684658		M>V	A:453	(-43.95, 74.31, 1.70)
2:148684697	COSM1007190 COSM1007192	A>T	A:466	(-39.52, 71.58, 21.11)
2:148684728		G>D	A:476	(-49.68, 66.27, 6.67)

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:148676128	COSM3798024	L>Q	A:310	(-61.57, 51.91, 19.24)
2:148676144	COSM132653	K>N	A:315	(-54.68, 54.39, 20.37)
2:148677893	COSM1325886	A>T	A:353	(-43.13, 61.75, 35.35)
2:148680582	COSM1613466	G>V	A:373	(-29.82, 64.35, 28.90)
2:148680662	COSM441201	R>C	A:400	(-31.64, 60.75, -3.80)
2:148680663	COSM1399830	R>H	A:400	(-31.64, 60.75, -3.80)
2:148683656	COSM3713461	L>V	A:425	(-22.60, 61.85, 22.27)
2:148684674	COSM93851	I>T	A:458	(-37.76, 70.25, 7.28)
2:148684697	COSM1007190	A>S	A:466	(-39.52, 71.58, 21.11)
2:148684734	COSM1399833	R>I	A:478	(-47.35, 72.34, 6.45)
2:148684735	COSM1613471	R>S	A:478	(-47.35, 72.34, 6.45)
2:148684739	COSM1613472	T>A	A:480	(-51.77, 67.89, 1.35)

4ASX.A | ACVR2A.