4H1Y.P | NT5E – ASTRID

4H1Y.P | NT5E

General Structure Information

PDB ID	4h1y
HGNC Gene Label(s)	NT5E
Structure Name	human ecto-5-nucleotidase (cd73): crystal form ii (open) in complex with psb11552
Resolution	1.58Å
Reference	AUTH K.KNAPP,M.ZEBISCH,J.PIPPEL,A.EL-TAYEB,C.E.MULLER,N.STRATERTITL CRYSTAL STRUCTURE OF THE HUMAN ECTO-5-NUCLEOTIDASE (CD73):TITL 2 INSIGHTS INTO THE REGULATION OF PURINERGIC SIGNALING.REF STRUCTURE V. 20 2161 2012REFN ISSN 0969-2126PMID 23142347DOI 10.1016/J.STR.2012.10.001

Variant Set Distributions

ExAC Variants

Number Of Residues	523
Number Of SNVs	144
Number Of Permutations	67687
Optimal Distance Threshold	7.0
K Statistic	0.013
p-value	0.512

COSMIC

Number Of Residues	523
Number Of SNVs	5
Number Of Permutations	1491
Optimal Distance Threshold	15.0
K Statistic	0.4
p-value	0.092

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	144
Number Of COSMIC SNVs	5
Optimal Distance Threshold	15.0
K Statistic	0.295
p-value	0.181

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
6:86159958		T>S	P:34	(19.47, 33.63, 14.38)
6:86159970		H>R	P:38	(21.37, 24.13, 18.86)
6:86159981		E>Q	P:42	(10.33, 20.29, 13.42)
6:86159985	rs534674647	Q>R	P:43	(6.48, 23.57, 15.12)
6:86159990		S>G	P:45	(7.34, 23.55, 22.67)
6:86159998	rs369010777	D>E	P:47	(9.94, 23.87, 26.33)
6:86160009		C>Y	P:51	(5.19, 19.70, 19.03)
6:86160015	rs374757389	N>S	P:53	(-0.75, 21.95, 21.23)
6:86160024	rs369193143	R>H	P:56	(-0.49, 26.57, 23.06)
6:86160033		G>D	P:59	(8.93, 28.12, 15.43)
6:86160041	rs200250022	A>S	P:62	(8.46, 27.71, 8.29)
6:86160054		T>I	P:66	(6.50, 33.78, 7.16)
6:86160059		V>I	P:68	(12.00, 36.96, 6.94)
6:86160068		I>V	P:71	(10.56, 41.93, 7.57)
6:86160083		P>T	P:76	(14.62, 48.65, 2.39)
6:86160087		N>S	P:77	(18.10, 48.35, 3.83)
6:86160089		V>M	P:78	(17.48, 43.43, 5.26)
6:86160101		D>H	P:82	(23.43, 32.62, 12.35)
6:86160104		A>T	P:83	(25.74, 33.40, 15.54)
6:86160114		Q>P	P:86	(22.10, 26.05, 13.07)
6:86160138	rs568624079	T>N	P:94	(21.72, 12.46, 13.97)
6:86160170		M>V	P:105	(20.50, 28.58, 6.41)
6:86160188		D>Y	P:111	(22.90, 37.50, 4.21)
6:86176789		N>K	P:117	(30.74, 25.41, 19.71)
6:86176804		N>K	P:122	(30.86, 15.92, 13.25)
6:86176815		G>E	P:126	(31.76, 18.04, 9.16)
6:86176823		E>Q	P:129	(32.37, 17.84, 3.34)
6:86176839		E>G	P:134	(26.67, 22.76, -0.17)
6:86176844		K>E	P:136	(23.92, 29.34, -1.62)
6:86176853		I>V	P:139	(30.65, 30.67, 6.74)
6:86176863		A>V	P:142	(38.83, 35.83, 12.55)
6:86176877		K>Q	P:147	(48.17, 24.16, 10.11)
6:86176879		K>N	P:147	(48.17, 24.16, 10.11)
6:86176889		A>P	P:151	(45.32, 25.11, 5.32)
6:86176895	rs200369370	Q>E	P:153	(42.52, 20.82, 2.97)
6:86176896		Q>R	P:153	(42.52, 20.82, 2.97)
6:86176916		P>T	P:160	(37.75, 36.73, 8.03)
6:86176932		P>L	P:165	(26.09, 44.34, -0.95)
6:86176941		D>V	P:168	(23.27, 52.20, -3.01)
6:86176946		V>L	P:170	(28.91, 48.58, 1.86)
6:86176955		I>V	P:173	(30.00, 41.01, 8.39)
6:86176956		I>T	P:173	(30.00, 41.01, 8.39)
6:86176958	COSM1187100	V>I	P:174	(33.67, 40.51, 11.77)
6:86176961		G>R	P:175	(34.06, 37.01, 12.86)
6:86176964		Y>H	P:176	(32.87, 36.59, 17.26)
6:86176998		P>L	P:187	(38.22, 20.90, 16.76)
6:86180961		N>T	P:190	(45.33, 20.76, 12.64)
6:86180976		D>G	P:195	(41.93, 36.63, 21.74)
6:86181003		V>E	P:204	(38.10, 46.32, 11.94)
6:86181026		V>M	P:212	(34.18, 49.70, 5.16)
6:86181029		N>Y	P:213	(31.56, 53.26, 7.18)
6:86181039		I>T	P:216	(28.28, 43.86, 11.79)
6:86181051		H>R	P:220	(29.26, 31.30, 19.26)
6:86181059		F>V	P:223	(26.11, 39.27, 27.02)
6:86181069		D>G	P:226	(29.59, 39.80, 22.94)
6:86181074	rs144535109	L>F	P:228	(34.71, 42.70, 26.39)
6:86181095	rs200664520 COSM3922218 COSM3922219	G>S	P:235	(34.72, 50.18, 14.87)
6:86181098		V>M	P:236	(32.58, 47.64, 16.23)
6:86181104	rs550591725	V>L	P:238	(26.78, 46.23, 15.83)
6:86181110	rs201657741	V>M	P:240	(25.42, 39.92, 16.49)
6:86181123		S>C	P:244	(24.79, 32.53, 26.17)
6:86181137		Y>H	P:249	(12.01, 42.37, 25.26)
6:86181143		G>R	P:251	(9.90, 45.33, 28.19)
6:86194979	rs565537252 COSM1312417	A>S	P:260	(19.44, 39.94, 31.05)
6:86194992		P>Q	P:264	(19.69, 47.14, 22.54)
6:86195000		V>I	P:267	(28.56, 49.15, 25.29)
6:86195018	COSM197578	R>W	P:273	(31.78, 54.21, 19.55)
6:86195019		R>Q	P:273	(31.78, 54.21, 19.55)
6:86195024		V>L	P:275	(28.12, 49.70, 20.94)
6:86195025		V>A	P:275	(28.12, 49.70, 20.94)
6:86195033	rs41271617	V>I	P:278	(22.29, 41.82, 19.96)
6:86195034		V>A	P:278	(22.29, 41.82, 19.96)
6:86195040		A>D	P:280	(18.08, 35.62, 20.39)
6:86195045		A>S	P:282	(17.43, 29.83, 21.44)
6:86195074		K>N	P:291	(15.25, 49.20, 12.88)
6:86195078		E>K	P:293	(19.18, 55.56, 12.30)
6:86195079		E>A	P:293	(19.18, 55.56, 12.30)
6:86195099	rs148199616	V>I	P:300	(25.30, 54.67, 15.29)
6:86195111	COSM1239645	H>Y	P:304	(14.73, 50.57, 17.31)
6:86195112		H>R	P:304	(14.73, 50.57, 17.31)
6:86195120		P>S	P:307	(13.02, 40.08, 20.33)
6:86195123		I>V	P:308	(9.98, 38.76, 16.80)
6:86195124	rs201782026	I>T	P:308	(9.98, 38.76, 16.80)
6:86195140		S>R	P:313	(0.22, 34.20, 15.00)
6:86197055		P>T	P:318	(3.19, 26.43, 2.99)
6:86197068	rs570714428	A>V	P:322	(6.46, 20.43, 2.70)
6:86197078		N>K	P:325	(6.78, 17.15, 6.22)
6:86197082	rs147019457	W>R	P:327	(14.89, 17.00, 4.09)
6:86197089		I>T	P:329	(10.28, 10.30, 5.44)
6:86197098	COSM3875894	D>G	P:332	(10.27, 8.72, 10.78)
6:86197121		G>R	P:340	(22.49, -1.82, 19.02)
6:86197149		S>C	P:349	(13.15, 1.75, 37.10)
6:86197157		S>T	P:352	(15.76, 1.44, 40.80)
6:86197163	rs200648774	R>C	P:354	(13.04, 8.28, 41.41)
6:86197176	rs387906620 CM110837	C>Y	P:358	(20.88, 2.31, 38.03)
6:86197199		D>H	P:366	(29.63, 5.79, 31.25)
6:86197200		D>A	P:366	(29.63, 5.79, 31.25)
6:86197207		M>I	P:368	(27.55, 11.92, 29.85)
6:86199224		L>V	P:373	(36.64, 12.14, 25.45)
6:86199233	rs2229523	T>A	P:376	(44.96, 16.54, 25.97)
6:86199243	rs2229524	M>T	P:379	(48.63, 18.88, 32.89)
6:86199244		M>I	P:379	(48.63, 18.88, 32.89)
6:86199257	rs375139069	V>I	P:384	(35.88, 15.71, 32.20)
6:86199264	rs551037246	M>T	P:386	(33.14, 14.13, 37.44)
6:86199267		C>Y	P:387	(28.57, 12.34, 36.01)
6:86199278		G>R	P:391	(16.37, 9.93, 38.16)
6:86199291		R>Q	P:395	(10.79, 9.32, 32.97)
6:86199293	rs566262245	S>P	P:396	(12.35, 3.87, 30.52)
6:86199300		I>T	P:398	(15.66, -0.68, 27.38)
6:86199308	rs144719925	R>C	P:401	(14.20, -11.17, 27.26)
6:86199309	rs139549986	R>P	P:401	(14.20, -11.17, 27.26)
6:86199314	rs138876213	N>H	P:403	(17.76, -9.90, 19.22)
6:86199315		N>S	P:403	(17.76, -9.90, 19.22)
6:86200228		T>P	P:405	(17.51, -4.30, 19.61)
6:86200242		E>D	P:409	(11.40, 4.58, 19.24)
6:86200250		A>V	P:412	(13.19, 8.62, 23.57)
6:86200268	rs146054415	G>E	P:418	(15.11, 17.78, 25.19)
6:86200274	rs370017735	T>I	P:420	(21.44, 19.07, 26.99)
6:86200277	rs72905321	F>Y	P:421	(23.64, 15.24, 28.69)
6:86200289		Q>P	P:425	(33.53, 24.84, 36.38)
6:86200297		G>C	P:428	(32.93, 20.70, 46.26)
6:86200298		G>V	P:428	(32.93, 20.70, 46.26)
6:86200319		F>S	P:435	(25.87, 13.93, 46.06)
6:86200324		H>D	P:437	(18.83, 17.83, 47.37)
6:86200330		V>M	P:439	(19.47, 11.80, 50.33)
6:86200331		V>G	P:439	(19.47, 11.80, 50.33)
6:86200336		R>C	P:441	(12.50, 14.50, 49.59)
6:86200337	rs377417331 COSM1082169	R>H	P:441	(12.50, 14.50, 49.59)
6:86200342	rs373069568 COSM1187101	G>S	P:443	(11.65, 7.32, 50.19)
6:86200351		T>A	P:446	(11.99, 11.88, 44.85)
6:86200360	rs376616753	F>L	P:449	(19.02, 9.14, 44.07)
6:86201699		I>M	P:455	(31.34, 10.07, 41.54)
6:86201719		S>F	P:462	(21.00, 7.32, 60.30)
6:86201722	rs201008460 COSM3430920	R>Q	P:463	(24.39, 10.91, 59.99)
6:86201731		G>E	P:466	(22.88, 17.18, 55.54)
6:86201733		D>N	P:467	(25.35, 14.82, 58.01)
6:86201742	rs142656691	V>I	P:470	(29.84, 9.23, 54.93)
6:86201767		K>T	P:478	(45.72, 15.81, 36.91)
6:86201768		K>N	P:478	(45.72, 15.81, 36.91)
6:86201791		P>L	P:486	(39.30, 12.32, 48.54)
6:86201797		K>R	P:488	(39.37, 17.85, 48.12)
6:86201799		M>L	P:489	(34.96, 21.32, 50.12)
6:86201805	rs143859595	E>K	P:491	(39.19, 21.07, 43.84)
6:86201812	rs151304292	Y>C	P:493	(35.98, 19.12, 41.38)
6:86201817		V>M	P:495	(30.54, 18.11, 36.18)
6:86201838		A>T	P:502	(22.12, 23.63, 35.60)
6:86201842		N>S	P:503	(18.89, 25.45, 34.85)
6:86201848		G>A	P:505	(16.35, 21.33, 39.22)
6:86201853		G>R	P:507	(16.31, 21.59, 43.91)
6:86201886	rs141170507	H>Y	P:518	(26.46, 26.31, 31.92)
6:86201890		D>G	P:519	(29.28, 25.52, 28.64)
6:86203567		D>Y	P:524	(19.69, 13.86, 25.68)
6:86203576		V>M	P:527	(25.18, 11.27, 24.01)
6:86203585	rs34160251	T>A	P:530	(27.05, 7.87, 19.74)
6:86203592		I>N	P:532	(24.91, 2.31, 22.10)
6:86203604		K>R	P:536	(29.21, -2.54, 18.30)
6:86203607		V>A	P:537	(27.67, -5.15, 22.67)
6:86203609		I>V	P:538	(25.74, -2.65, 26.04)
6:86203612		Y>H	P:539	(28.92, -5.64, 29.09)
6:86203615		P>T	P:540	(25.53, -2.25, 31.83)
6:86203630		R>W	P:545	(29.20, 3.88, 39.93)
6:86203631	rs371449832 COSM1487963	R>Q	P:545	(29.20, 3.88, 39.93)

4H1Y.P | NT5E.

4H1Y.P | NT5E

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
6:86159948	COSM3662747	I>V	P:31	(20.04, 43.55, 11.91)
6:86160088	COSM3662748	N>K	P:77	(18.10, 48.35, 3.83)
6:86195018	COSM197578	R>W	P:273	(31.78, 54.21, 19.55)
6:86195099	COSM75659	V>I	P:300	(25.30, 54.67, 15.29)
6:86197130	COSM75660	I>V	P:343	(23.82, -8.72, 26.86)