General Structure Information
| PDB ID | 1w2c |
| HGNC Gene Label(s) | ITPKA |
| Structure Name | human inositol (1,4,5) trisphosphate 3-kinase complexed with mn2+/amppnp/ins(1,4,5)p3 |
| Resolution | 1.95Å |
| Reference | AUTH B.GONZALEZ,M.J.SCHELL,A.J.LETCHER,D.B.VEPRINTSEV,R.F.IRVINE,AUTH 2 R.L.WILLIAMSTITL STRUCTURE OF A HUMAN INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE;TITL 2 SUBSTRATE BINDING REVEALS WHY IT IS NOT A PHOSPHOINOSITIDETITL 3 3-KINASEREF MOL.CELL V. 15 689 2004REFN ISSN 1097-2765PMID 15350214DOI 10.1016/J.MOLCEL.2004.08.004 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 265 |
| Number Of SNVs | 54 |
| Number Of Permutations | 7204 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.191 |
| p-value | 0.035 |