1K95.A | GCA – ASTRID

1K95.A | GCA

General Structure Information

PDB ID	1k95
HGNC Gene Label(s)	GCA
Structure Name	crystal structure of des(1-52)grancalcin with bound calcium
Resolution	1.9Å
Reference	AUTH J.JIA,N.BORREGAARD,K.LOLLIKE,M.CYGLERTITL STRUCTURE OF CA(2+)-LOADED HUMAN GRANCALCIN.REF ACTA CRYSTALLOGR.,SECT.D V. 57 1843 2001REFN ISSN 0907-4449PMID 11717497DOI 10.1107/S0907444901016511

Variant Set Distributions

ExAC Variants

Number Of Residues	161
Number Of SNVs	52
Number Of Permutations	13301
Optimal Distance Threshold	14.0
K Statistic	0.198
p-value	0.293

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:163204221		V>A	A:54	(51.71, 5.26, 44.54)
2:163204226		T>A	A:56	(55.33, 2.47, 40.84)
2:163204241		V>F	A:61	(47.98, 2.21, 35.44)
2:163208857		V>M	A:68	(45.87, 8.79, 33.46)
2:163208861		D>V	A:69	(41.88, 7.54, 31.90)
2:163208876	rs373720297	Q>R	A:74	(39.08, 3.59, 39.27)
2:163208877	rs79565841	Q>H	A:74	(39.08, 3.59, 39.27)
2:163208881		C>R	A:76	(45.90, 3.81, 40.67)
2:163208884		L>M	A:77	(43.69, 5.63, 43.43)
2:163208890		Q>E	A:79	(47.03, -0.57, 42.85)
2:163208893	rs17783344	S>A	A:80	(47.06, 2.90, 46.52)
2:163208917		P>S	A:88	(36.42, 1.62, 45.73)
2:163212954		S>N	A:90	(33.89, 6.45, 41.58)
2:163212974	COSM3961381	M>L	A:97	(39.92, 13.60, 40.82)
2:163212976		M>I	A:97	(39.92, 13.60, 40.82)
2:163213278		T>K	A:106	(43.60, 16.64, 28.07)
2:163213286		M>V	A:109	(46.18, 13.24, 35.50)
2:163213297		N>K	A:112	(53.58, 16.76, 37.71)
2:163213305	rs376239356	K>R	A:115	(53.07, 14.89, 42.61)
2:163213334		K>E	A:125	(42.39, 10.01, 54.38)
2:163213340		N>D	A:127	(40.23, 16.38, 57.34)
2:163213346		M>V	A:129	(40.82, 10.15, 59.62)
2:163213348	rs574274580	M>I	A:129	(40.82, 10.15, 59.62)
2:163213352		V>L	A:131	(35.48, 14.13, 61.39)
2:163213356		D>V	A:132	(35.02, 9.28, 61.23)
2:163213362		D>G	A:134	(34.09, 4.76, 65.45)
2:163213367		S>G	A:136	(32.92, 4.90, 59.66)
2:163213373		T>A	A:138	(29.92, 7.01, 56.84)
2:163213382		H>Y	A:141	(24.52, 16.12, 57.67)
2:163213394	rs563127943	R>C	A:145	(27.69, 21.34, 58.35)
2:163213395	rs374402814	R>H	A:145	(27.69, 21.34, 58.35)
2:163213406		G>C	A:149	(36.13, 24.09, 57.88)
2:163213414		M>I	A:151	(38.70, 22.33, 53.84)
2:163215563		L>S	A:155	(30.18, 28.15, 53.80)
2:163215580		T>A	A:161	(22.26, 22.12, 54.33)
2:163215583	rs184430160	T>A	A:162	(22.64, 22.32, 50.00)
2:163215589		V>L	A:164	(25.26, 17.98, 53.36)
2:163215595	rs377112025 COSM1008382	R>C	A:166	(24.22, 16.10, 45.65)
2:163215601	rs146161584	S>G	A:168	(23.59, 12.37, 51.34)
2:163215611		G>D	A:171	(22.29, 10.65, 55.74)
2:163215624		F>L	A:175	(36.26, 8.36, 51.49)
2:163215632		Y>C	A:178	(34.88, 13.78, 52.23)
2:163215650	rs367777675	K>T	A:184	(32.25, 20.16, 42.79)
2:163215656		R>Q	A:186	(40.81, 22.59, 44.76)
2:163215659		A>V	A:187	(37.03, 23.48, 41.37)
2:163215665		T>I	A:189	(36.74, 28.00, 44.44)
2:163215667		D>N	A:190	(39.84, 27.20, 41.59)
2:163216016	rs558963969	K>R	A:194	(40.02, 31.99, 37.35)
2:163216028		L>S	A:198	(38.97, 42.96, 43.50)
2:163216043	rs558346557	A>V	A:203	(31.73, 37.68, 40.68)
2:163216053	rs368854743	I>M	A:206	(29.71, 36.51, 30.83)
2:163216054		Y>H	A:207	(25.21, 31.67, 29.80)
2:163216057	rs146185329	D>N	A:208	(29.90, 31.16, 27.41)
2:163216060	COSM1008383	D>N	A:209	(32.82, 32.00, 31.35)
2:163216739		T>A	A:214	(30.48, 25.11, 35.60)
2:163216742		M>V	A:215	(29.62, 22.09, 32.22)