General Structure Information
| PDB ID | 4iar |
| HGNC Gene Label(s) | HTR1B |
| Structure Name | crystal structure of the chimeric protein of 5-ht1b-bril in complex with ergotamine (psi community target) |
| Resolution | 2.7Å |
| Reference | AUTH C.WANG,Y.JIANG,J.MA,H.WU,D.WACKER,V.KATRITCH,G.W.HAN,W.LIU,AUTH 2 X.P.HUANG,E.VARDY,J.D.MCCORVY,X.GAO,X.E.ZHOU,K.MELCHER,AUTH 3 C.ZHANG,F.BAI,H.YANG,L.YANG,H.JIANG,B.L.ROTH,V.CHEREZOV,AUTH 4 R.C.STEVENS,H.E.XUTITL STRUCTURAL BASIS FOR MOLECULAR RECOGNITION AT SEROTONINTITL 2 RECEPTORS.REF SCIENCE V. 340 610 2013REFN ISSN 0036-8075PMID 23519210DOI 10.1126/SCIENCE.1232807 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 273 |
| Number Of SNVs | 56 |
| Number Of Permutations | 10316 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.264 |
| p-value | 0.518 |
COSMIC
| Number Of Residues | 273 |
| Number Of SNVs | 6 |
| Number Of Permutations | 931 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.2 |
| p-value | 0.903 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 56 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.072 |
| p-value | 0.841 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
