General Structure Information
| PDB ID | 3txo |
| HGNC Gene Label(s) | PRKCH |
| Structure Name | pkc eta kinase in complex with a naphthyridine |
| Resolution | 2.05Å |
| Reference | AUTH M.J.VAN EIS,J.P.EVENOU,P.FLOERSHEIM,C.GAUL,S.W.COWAN-JACOB,AUTH 2 L.MONOVICH,G.RUMMEL,W.SCHULER,W.STARK,A.STRAUSS,A.MATT,AUTH 3 E.VANGREVELINGHE,J.WAGNER,N.SOLDERMANNTITL 2,6-NAPHTHYRIDINES AS POTENT AND SELECTIVE INHIBITORS OF THETITL 2 NOVEL PROTEIN KINASE C ISOZYMES.REF BIOORG.MED.CHEM.LETT. V. 21 7367 2011REFN ISSN 0960-894XPMID 22078216DOI 10.1016/J.BMCL.2011.10.025 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 317 |
| Number Of SNVs | 70 |
| Number Of Permutations | 12748 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.061 |
| p-value | 0.617 |
COSMIC
| Number Of Residues | 317 |
| Number Of SNVs | 9 |
| Number Of Permutations | 1545 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.083 |
| p-value | 0.3 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 70 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | -0.208 |
| p-value | 0.154 |