General Structure Information
| PDB ID | 1fgu |
| HGNC Gene Label(s) | RPA1 |
| Structure Name | ssdna-binding domain of the large subunit of replication protein a |
| Resolution | 2.5Å |
| Reference | AUTH E.BOCHKAREVA,V.BELEGU,S.KOROLEV,A.BOCHKAREVTITL STRUCTURE OF THE MAJOR SINGLE-STRANDED DNA-BINDINGTITL 2 DOMAIN OF REPLICATION PROTEIN A SUGGESTS A DYNAMICTITL 3 MECHANISM FOR DNA BINDING.REF EMBO J. V. 20 612 2001REFN ISSN 0261-4189PMID 11157767DOI 10.1093/EMBOJ/20.3.612 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 237 |
| Number Of SNVs | 67 |
| Number Of Permutations | 14039 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.305 |
| p-value | 0.047 |
COSMIC
| Number Of Residues | 237 |
| Number Of SNVs | 6 |
| Number Of Permutations | 3775 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.133 |
| p-value | 0.504 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 67 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | -0.176 |
| p-value | 0.236 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
