General Structure Information
| PDB ID | 4awn |
| HGNC Gene Label(s) | DNASE1 |
| Structure Name | structure of recombinant human dnase i (rhdnasei) in complex with magnesium and phosphate. |
| Resolution | 1.95Å |
| Reference | AUTH G.PARSIEGLA,C.NOGUERE,L.SANTELL,R.A.LAZARUS,Y.BOURNETITL THE STRUCTURE OF HUMAN DNASE I BOUND TO MAGNESIUM ANDTITL 2 PHOSPHATE IONS POINTS TO A CATALYTIC MECHANISM COMMON TOTITL 3 MEMBERS OF THE DNASE I-LIKE SUPERFAMILY.REF BIOCHEMISTRY V. 51 10250 2012REFN ISSN 0006-2960PMID 23215638DOI 10.1021/BI300873F |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 260 |
| Number Of SNVs | 104 |
| Number Of Permutations | 9844 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.018 |
| p-value | 0.653 |
COSMIC
| Number Of Residues | 260 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1318 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.4 |
| p-value | 0.448 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 104 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.297 |
| p-value | 0.215 |