General Structure Information
| PDB ID | 3v4p |
| HGNC Gene Label(s) | ITGB7 |
| Structure Name | crystal structure of a4b7 headpiece complexed with fab act-1 |
| Resolution | 3.15Å |
| Reference | AUTH Y.YU,J.ZHU,L.Z.MI,T.WALZ,H.SUN,J.CHEN,T.A.SPRINGERTITL STRUCTURAL SPECIALIZATIONS OF A4B7, AN INTEGRIN THATTITL 2 MEDIATES ROLLING ADHESIONREF J.CELL BIOL. V. 196 131 2012REFN ISSN 0021-9525PMID 22232704DOI 10.1083/JCB.201110023 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 375 |
| Number Of SNVs | 78 |
| Number Of Permutations | 52380 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.158 |
| p-value | 0.098 |
COSMIC
| Number Of Residues | 375 |
| Number Of SNVs | 3 |
| Number Of Permutations | 66 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 78 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 36.0 |
| K Statistic | -0.354 |
| p-value | 0.538 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
