General Structure Information
| PDB ID | 3ipy |
| HGNC Gene Label(s) | DCK |
| Structure Name | x-ray structure of human deoxycytidine kinase in complex with an inhibitor |
| Resolution | 2.54Å |
| Reference | AUTH T.C.JESSOP,J.E.TARVER,M.CARLSEN,A.XU,J.P.HEALY,AUTH 2 A.HEIM-RIETHER,Q.FU,J.A.TAYLOR,D.J.AUGERI,M.SHEN,T.R.STOUCH,AUTH 3 R.V.SWANSON,L.W.TARI,M.HUNTER,I.HOFFMAN,P.E.KEYES,X.C.YU,AUTH 4 M.MIRANDA,Q.LIU,J.C.SWAFFIELD,S.DAVID KIMBALL,A.NOURALDEEN,AUTH 5 A.G.WILSON,A.M.FOUSHEE,K.JHAVER,R.FINCH,S.ANDERSON,AUTH 6 T.ORAVECZ,K.G.CARSONTITL LEAD OPTIMIZATION AND STRUCTURE-BASED DESIGN OF POTENT ANDTITL 2 BIOAVAILABLE DEOXYCYTIDINE KINASE INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 19 6784 2009REFN ISSN 0960-894XPMID 19836232DOI 10.1016/J.BMCL.2009.09.081 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 225 |
| Number Of SNVs | 47 |
| Number Of Permutations | 4766 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.082 |
| p-value | 0.33 |
COSMIC
| Number Of Residues | 225 |
| Number Of SNVs | 3 |
| Number Of Permutations | 161 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.667 |
| p-value | 0.497 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 47 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.41 |
| p-value | 0.636 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
