General Structure Information
| PDB ID | 2w99 |
| HGNC Gene Label(s) | CCND1 |
| Structure Name | crystal structure of cdk4 in complex with a d-type cyclin |
| Resolution | 2.8Å |
| Reference | AUTH P.J.DAY,A.CLEASBY,I.J.TICKLE,M.OREILLY,J.E.COYLE,AUTH 2 F.P.HOLDING,R.L.MCMENAMIN,J.YON,R.CHOPRA,AUTH 3 C.LENGAUER,H.JHOTITITL CRYSTAL STRUCTURE OF HUMAN CDK4 IN COMPLEX WITH ATITL 2 D-TYPE CYCLIN.REF PROC.NATL.ACAD.SCI.USA V. 106 4166 2009REFN ISSN 0027-8424PMID 19237565DOI 10.1073/PNAS.0809645106 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 246 |
| Number Of SNVs | 46 |
| Number Of Permutations | 7356 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.048 |
| p-value | 0.099 |
COSMIC
| Number Of Residues | 246 |
| Number Of SNVs | 4 |
| Number Of Permutations | 153 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.5 |
| p-value | 0.021 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 46 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.129 |
| p-value | 0.632 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
