General Structure Information
| PDB ID | 3qak |
| HGNC Gene Label(s) | ADORA2A |
| Structure Name | agonist bound structure of the human adenosine a2a receptor |
| Resolution | 2.71Å |
| Reference | AUTH F.XU,H.WU,V.KATRITCH,G.W.HAN,K.A.JACOBSON,Z.G.GAO,AUTH 2 V.CHEREZOV,R.C.STEVENSTITL STRUCTURE OF AN AGONIST-BOUND HUMAN A2A ADENOSINE RECEPTOR.REF SCIENCE V. 332 322 2011REFN ISSN 0036-8075PMID 21393508DOI 10.1126/SCIENCE.1202793 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 284 |
| Number Of SNVs | 69 |
| Number Of Permutations | 47504 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.155 |
| p-value | 0.012 |
COSMIC
| Number Of Residues | 284 |
| Number Of SNVs | 5 |
| Number Of Permutations | 893 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.4 |
| p-value | 0.308 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 69 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.265 |
| p-value | 0.448 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
