3F8U.C | PDIA3

General Structure Information

PDB ID	3f8u
HGNC Gene Label(s)	PDIA3
Structure Name	tapasin/erp57 heterodimer
Resolution	2.6Å
Reference	AUTH G.DONG,P.A.WEARSCH,D.R.PEAPER,P.CRESSWELL,K.M.REINISCHTITL INSIGHTS INTO MHC CLASS I PEPTIDE LOADING FROM THE STRUCTURETITL 2 OF THE TAPASIN-ERP57 THIOL OXIDOREDUCTASE HETERODIMER.REF IMMUNITY V. 30 21 2009REFN ISSN 1074-7613PMID 19119025DOI 10.1016/J.IMMUNI.2008.10.018

Variant Set Distributions

ExAC Variants

Number Of Residues	462
Number Of SNVs	110
Number Of Permutations	29332
Optimal Distance Threshold	30.0
K Statistic	0.347
p-value	0.617

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
15:44038814		D>G	C:26	(28.40, 85.10, 40.18)
15:44038833		D>E	C:32	(42.72, 90.90, 54.67)
15:44038834		D>Y	C:33	(37.75, 91.91, 56.70)
15:44038835		D>G	C:33	(37.75, 91.91, 56.70)
15:44038843		E>K	C:36	(39.96, 83.29, 57.68)
15:44038847		S>T	C:37	(34.60, 84.02, 57.44)
15:44038850	rs61734331	R>L	C:38	(32.70, 85.25, 52.87)
15:44038854		I>M	C:39	(37.08, 80.44, 53.24)
15:44038858	rs4080719	D>Y	C:41	(30.55, 79.98, 53.19)
15:44038874		G>D	C:46	(33.64, 72.56, 50.62)
15:44038879		M>L	C:48	(36.04, 78.32, 47.69)
15:44038900		P>S	C:55	(44.95, 94.73, 38.95)
15:44046037	rs535800039	K>N	C:61	(44.19, 92.16, 32.72)
15:44046041	rs139502481	L>I	C:63	(41.41, 84.66, 33.97)
15:44046052		E>D	C:66	(37.32, 82.71, 30.94)
15:44046092		L>V	C:80	(34.53, 81.05, 42.09)
15:44048857	rs373449252	T>I	C:86	(47.29, 95.20, 46.02)
15:44048863		N>S	C:88	(44.31, 92.21, 50.67)
15:44048878		N>S	C:93	(51.84, 87.19, 52.66)
15:44048889		V>I	C:97	(51.03, 84.67, 46.77)
15:44048896		G>E	C:99	(51.84, 85.09, 41.66)
15:44048916	COSM3420319	F>L	C:106	(40.84, 77.17, 49.93)
15:44048923		D>A	C:108	(36.14, 72.49, 54.89)
15:44048934		A>T	C:112	(43.73, 72.11, 48.68)
15:44048938	rs553813975	G>V	C:113	(45.76, 73.00, 46.33)
15:44048940		A>T	C:114	(46.69, 74.07, 43.22)
15:44048941		A>V	C:114	(46.69, 74.07, 43.22)
15:44048955		R>G	C:119	(44.97, 79.96, 33.68)
15:44053630		V>I	C:125	(33.59, 74.17, 35.06)
15:44053647	rs543412569	K>N	C:130	(35.48, 64.93, 39.23)
15:44053666	rs372871422	V>M	C:137	(29.41, 59.16, 40.68)
15:44053670		P>R	C:138	(26.46, 57.53, 42.33)
15:44053672		L>V	C:139	(25.57, 55.17, 38.56)
15:44053684		E>K	C:143	(20.13, 57.84, 32.18)
15:44053702	rs55968494	I>V	C:149	(30.20, 55.96, 29.62)
15:44053703		I>S	C:149	(30.20, 55.96, 29.62)
15:44053720	rs542820973	S>P	C:155	(35.31, 55.95, 32.61)
15:44053725		I>M	C:156	(36.92, 54.67, 36.44)
15:44055278		F>C	C:159	(30.33, 47.46, 37.95)
15:44055280		F>L	C:160	(30.69, 47.09, 43.58)
15:44055283		D>N	C:161	(26.04, 43.06, 44.46)
15:44055286		D>N	C:162	(27.71, 43.99, 48.83)
15:44055296	rs199676605	S>N	C:165	(32.04, 45.29, 49.82)
15:44055300		E>D	C:166	(37.05, 44.52, 51.36)
15:44055310		E>K	C:170	(39.81, 49.15, 48.79)
15:44055322		A>T	C:174	(40.82, 55.18, 44.98)
15:44055332	COSM1740166	N>S	C:177	(43.46, 58.51, 46.59)
15:44055333		N>K	C:177	(43.46, 58.51, 46.59)
15:44055336	rs368603838	L>F	C:178	(43.14, 58.70, 41.95)
15:44055343	rs202041084	N>D	C:181	(44.00, 62.50, 38.04)
15:44055344	rs139812953	N>S	C:181	(44.00, 62.50, 38.04)
15:44055350		R>Q	C:183	(35.21, 60.48, 34.83)
15:44055379	rs192183348	V>M	C:193	(26.26, 44.32, 38.19)
15:44055385	rs200051575 COSM1373069	E>Q	C:195	(26.48, 43.86, 31.04)
15:44055392	rs201790285	D>G	C:197	(31.16, 40.93, 36.90)
15:44055400		G>R	C:200	(29.57, 41.22, 41.82)
15:44057650		G>V	C:202	(33.98, 45.15, 39.35)
15:44057665	rs113762568	R>H	C:207	(39.93, 52.96, 26.45)
15:44057670		S>A	C:209	(33.73, 56.71, 22.14)
15:44057673		H>Y	C:210	(36.40, 60.25, 20.87)
15:44057674		H>R	C:210	(36.40, 60.25, 20.87)
15:44057710		Y>C	C:222	(40.88, 44.65, 38.48)
15:44057715	COSM555204	E>Q	C:224	(44.37, 41.73, 40.08)
15:44057724		M>V	C:227	(39.59, 44.73, 44.61)
15:44057734	rs567884544	G>D	C:230	(46.67, 50.06, 44.61)
15:44057746		K>R	C:234	(49.28, 50.17, 40.30)
15:44057763	rs149089784	I>V	C:240	(43.93, 55.09, 30.91)
15:44058098		P>S	C:245	(47.24, 58.07, 22.76)
15:44058103		H>Q	C:246	(44.83, 63.32, 21.63)
15:44058107		T>A	C:248	(46.69, 66.68, 25.41)
15:44058108		T>R	C:248	(46.69, 66.68, 25.41)
15:44058132		Q>R	C:256	(56.20, 63.25, 26.52)
15:44058146	rs151274866	L>V	C:261	(55.67, 57.54, 17.33)
15:44058165		V>A	C:267	(44.49, 66.63, 16.06)
15:44058182		A>T	C:273	(36.92, 64.24, 13.84)
15:44058189		G>A	C:275	(39.72, 62.91, 10.29)
15:44058195		N>S	C:277	(39.68, 58.74, 13.60)
15:44058937		V>A	C:286	(51.37, 50.18, 11.43)
15:44058965		H>Q	C:295	(58.70, 45.18, 17.80)
15:44058993	rs575256148	K>E	C:305	(48.07, 74.49, 15.91)
15:44059048		I>T	C:323	(50.27, 65.82, 5.22)
15:44059054		V>A	C:325	(54.54, 64.77, 10.58)
15:44059062		I>V	C:328	(60.81, 58.53, 17.15)
15:44059092		M>L	C:338	(59.03, 59.96, 8.53)
15:44059108		S>L	C:343	(51.36, 56.60, 3.24)
15:44060688	COSM962059	R>C	C:344	(46.16, 58.80, 2.29)
15:44060724		Y>H	C:356	(63.16, 52.53, 15.73)
15:44060731		D>G	C:358	(66.04, 46.96, 11.87)
15:44060748		Y>D	C:364	(67.32, 65.93, 13.44)
15:44060755		K>R	C:366	(70.17, 72.15, 14.91)
15:44060769		P>A	C:371	(82.46, 71.78, 5.98)
15:44060779	rs374627089	N>S	C:374	(87.68, 71.44, 7.92)
15:44061726		A>V	C:383	(76.67, 68.25, 14.76)
15:44061730	rs375102239 COSM962061	E>D	C:384	(76.46, 66.19, 10.72)
15:44061732	rs368148196	N>S	C:385	(81.60, 66.89, 12.47)
15:44061749	rs200746018	N>D	C:391	(84.69, 62.37, 20.40)
15:44061750		N>S	C:391	(84.69, 62.37, 20.40)
15:44061763		K>N	C:395	(93.39, 63.47, 18.62)
15:44061779		F>L	C:401	(81.13, 75.36, 22.32)
15:44061804		C>Y	C:409	(83.48, 85.77, 20.50)
15:44061807		K>R	C:410	(84.67, 89.73, 16.68)
15:44061818		P>S	C:414	(91.63, 86.43, 16.21)
15:44061819		P>L	C:414	(91.63, 86.43, 16.21)
15:44061822	rs6413485	K>R	C:415	(93.24, 86.22, 20.34)
15:44062454		K>Q	C:425	(104.09, 71.80, 13.30)
15:44062469	rs375987208	V>I	C:430	(92.47, 69.54, 17.61)
15:44062476	rs199671931	A>V	C:432	(87.94, 73.75, 17.55)
15:44062494		A>D	C:438	(73.47, 76.27, 14.71)
15:44062526		G>S	C:449	(77.80, 80.98, 27.57)
15:44062733		I>M	C:453	(86.06, 77.11, 26.16)
15:44062774	rs377493395	Y>C	C:467	(89.81, 77.49, 29.62)
15:44063318		S>G	C:474	(99.22, 83.15, 26.85)
15:44063328		I>T	C:477	(100.05, 78.21, 24.98)
15:44063334		Y>F	C:479	(94.82, 74.43, 29.63)
15:44063336	rs377030034	L>V	C:480	(97.58, 73.22, 25.82)
15:44063348	rs149410584	A>T	C:484	(98.50, 67.78, 27.36)
15:44063357	rs542695609	P>T	C:487	(104.30, 66.26, 24.99)
15:44063360		P>S	C:488	(103.09, 70.16, 23.66)
15:44063367		I>S	C:490	(104.30, 75.22, 20.60)