2OO0.A | ODC1 – ASTRID

2OO0.A | ODC1

General Structure Information

PDB ID	2oo0
HGNC Gene Label(s)	ODC1
Structure Name	a structural insight into the inhibition of human and leishmania donovani ornithine decarboxylases by 3-aminooxy-1-aminopropane
Resolution	1.9Å
Reference	AUTH V.T.DUFE,D.INGNER,O.HEBY,A.R.KHOMUTOV,L.PERSSON,AUTH 2 S.AL-KARADAGHITITL A STRUCTURAL INSIGHT INTO THE INHIBITION OF HUMAN ANDTITL 2 LEISHMANIA DONOVANI ORNITHINE DECARBOXYLASES BYTITL 3 1-AMINO-OXY-3-AMINOPROPANE.REF BIOCHEM.J. V. 405 261 2007REFN ISSN 0264-6021PMID 17407445DOI 10.1042/BJ20070188

Variant Set Distributions

ExAC Variants

Number Of Residues	409
Number Of SNVs	91
Number Of Permutations	19553
Optimal Distance Threshold	8.0
K Statistic	0.023
p-value	0.706

COSMIC

Number Of Residues	409
Number Of SNVs	6
Number Of Permutations	541
Optimal Distance Threshold	19.0
K Statistic	0.133
p-value	0.84

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	91
Number Of COSMIC SNVs	6
Optimal Distance Threshold	21.0
K Statistic	-0.138
p-value	0.945

Pathogenic Proximity Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:10585142		N>S	A:6	(-41.22, -0.43, -3.85)
2:10585139	COSM1004746	E>V	A:7	(-42.72, -4.72, -6.23)
2:10585140	rs148808377	E>K	A:7	(-42.72, -4.72, -6.23)
2:10585125		H>Y	A:12	(-29.45, -7.83, -10.54)
2:10585121		F>Y	A:13	(-25.60, -7.12, -6.56)
2:10585116	rs140096943	D>N	A:15	(-21.68, -9.82, -8.59)
2:10585103		T>I	A:19	(-20.64, -5.89, -16.41)
2:10585101		A>T	A:20	(-24.11, -4.55, -17.71)
2:10585077		I>V	A:28	(-29.69, -13.16, -24.41)
2:10585064	rs371025449	S>F	A:32	(-31.69, -19.62, -25.98)
2:10584754	rs376445830	Y>C	A:41	(-33.86, -0.73, -22.83)
2:10584755		Y>N	A:41	(-33.86, -0.73, -22.83)
2:10584730		L>R	A:49	(-23.84, 7.30, -9.40)
2:10584701	rs114251583	L>F	A:59	(-18.97, 21.70, -13.42)
2:10584677	COSM269756	A>T	A:67	(-33.87, 16.68, -17.21)
2:10584640	rs373334646	T>N	A:79	(-30.99, 7.24, -8.27)
2:10584634		A>G	A:81	(-32.83, 11.91, -5.33)
2:10584626	rs138359527	G>R	A:84	(-29.00, 15.34, -4.66)
2:10584374		Q>R	A:99	(-43.38, 16.60, -5.08)
2:10584365	rs544366232	G>A	A:102	(-39.34, 13.56, -1.45)
2:10584363		V>M	A:103	(-37.93, 15.99, -3.69)
2:10584315	rs368830902	Q>E	A:119	(-49.73, 22.88, -15.32)
2:10584306		Y>N	A:122	(-49.87, 21.18, -8.99)
2:10584288	COSM132740	V>I	A:128	(-42.95, 25.01, -7.06)
2:10584284		Q>R	A:129	(-42.07, 29.15, -5.50)
2:10584275		T>S	A:132	(-38.68, 29.72, -16.57)
2:10584261		V>I	A:137	(-48.06, 36.86, -21.69)
2:10584251		M>T	A:140	(-49.60, 39.18, -17.94)
2:10584245	rs200293974	V>A	A:142	(-47.11, 34.75, -12.95)
2:10584242	rs140323723	A>V	A:143	(-49.59, 37.79, -11.67)
2:10584233		H>L	A:146	(-46.88, 31.57, -8.57)
2:10584221		K>R	A:150	(-38.96, 33.75, -6.84)
2:10583951		R>Q	A:154	(-34.96, 30.37, -21.79)
2:10583943		T>A	A:157	(-28.65, 30.91, -27.50)
2:10583940		D>N	A:158	(-25.42, 30.50, -31.31)
2:10583934	rs367574241	S>A	A:160	(-26.30, 27.30, -35.18)
2:10583925	rs114826666	V>I	A:163	(-28.16, 18.53, -32.97)
2:10583918	rs113241465	R>H	A:165	(-31.50, 25.52, -33.74)
2:10583919	COSM1326024	R>C	A:165	(-31.50, 25.52, -33.74)
2:10583894		T>M	A:173	(-33.71, 39.22, -27.06)
2:10583891		L>P	A:174	(-30.27, 41.00, -24.55)
2:10583885		T>N	A:176	(-36.93, 41.48, -24.88)
2:10583879	rs61733045	R>K	A:178	(-34.88, 47.14, -21.21)
2:10583865	rs115102834	R>W	A:183	(-44.81, 44.68, -17.24)
2:10583853	rs375812175	L>I	A:187	(-46.50, 43.20, -12.66)
2:10583843	rs377578357	D>G	A:190	(-38.86, 38.49, -7.78)
2:10583692		H>R	A:197	(-30.26, 24.99, -23.72)
2:10583684		S>G	A:200	(-29.28, 19.56, -27.58)
2:10583675		T>A	A:203	(-21.00, 21.42, -31.71)
2:10583672		D>N	A:204	(-19.45, 25.94, -30.46)
2:10583669		P>A	A:205	(-17.88, 25.24, -26.93)
2:10583662		T>I	A:207	(-22.04, 28.98, -27.38)
2:10583648		I>V	A:212	(-21.97, 33.09, -19.42)
2:10583644		S>C	A:213	(-21.70, 37.41, -21.42)
2:10583641		D>V	A:214	(-25.39, 37.58, -23.05)
2:10583630		V>I	A:218	(-29.58, 40.44, -17.93)
2:10583621	rs373045430	M>V	A:221	(-30.19, 44.98, -17.46)
2:10583423		S>T	A:228	(-31.49, 41.03, -6.31)
2:10583415		L>V	A:231	(-30.20, 31.75, -10.32)
2:10583405		I>T	A:234	(-25.64, 26.72, -17.53)
2:10583388		G>R	A:240	(-23.65, 10.97, -22.88)
2:10583378	rs548307029	D>V	A:243	(-19.46, 7.95, -29.63)
2:10583379		D>H	A:243	(-19.46, 7.95, -29.63)
2:10582291	rs573428254	V>I	A:254	(-14.85, 26.57, -22.03)
2:10582285		N>H	A:256	(-15.26, 26.57, -15.41)
2:10582278	rs375952999 COSM1727140	A>V	A:258	(-16.64, 32.15, -17.92)
2:10582249	rs61733046	G>R	A:268	(-23.40, 35.22, -4.86)
2:10582225	COSM1732451	G>S	A:276	(-29.77, 15.12, -19.34)
2:10582215		Y>C	A:279	(-26.62, 12.86, -14.96)
2:10582204		A>T	A:283	(-26.98, 3.68, -18.97)
2:10582197		T>M	A:285	(-28.09, -1.07, -23.59)
2:10582194		L>P	A:286	(-31.84, -1.65, -26.86)
2:10582164		V>E	A:296	(-32.48, -8.52, -51.90)
2:10582033		Q>H	A:312	(-26.45, -11.90, -50.97)
2:10581982		I>M	A:329	(-33.92, 8.39, -35.84)
2:10581968		A>E	A:334	(-30.10, 9.93, -34.16)
2:10581963		V>L	A:336	(-28.31, 4.43, -34.68)
2:10581956		P>L	A:338	(-25.63, -1.41, -35.42)
2:10581846		P>S	A:344	(-17.94, -11.50, -35.36)
2:10581829	rs138045213	K>N	A:349	(-19.20, -12.07, -46.76)
2:10581831		K>Q	A:349	(-19.20, -12.07, -46.76)
2:10581815		S>N	A:354	(-31.61, -3.16, -43.92)
2:10581782		R>L	A:365	(-35.44, 3.17, -42.90)
2:10581783	rs141834302	R>W	A:365	(-35.44, 3.17, -42.90)
2:10581770	rs573416709 COSM2981078	R>H	A:369	(-25.41, 0.87, -45.87)
2:10581771	rs371443385 COSM2981079	R>C	A:369	(-25.41, 0.87, -45.87)
2:10581751	rs367560002	M>I	A:375	(-27.89, -11.81, -38.89)
2:10581734	rs377240327 COSM1641606	M>T	A:381	(-29.37, -6.34, -33.27)
2:10581719		M>T	A:386	(-30.63, 4.08, -26.57)
2:10581711		Y>H	A:389	(-34.03, 12.97, -25.28)
2:10581689		T>M	A:396	(-48.19, 1.83, -28.42)
2:10581683		N>S	A:398	(-49.00, -1.31, -34.75)
2:10581674		Q>R	A:401	(-46.37, -2.74, -25.66)
2:10581665		T>M	A:404	(-38.74, -4.30, -19.97)
2:10581657		Y>H	A:407	(-33.40, -0.48, -13.94)
2:10581653		V>G	A:408	(-28.07, -2.98, -12.98)
2:10581638	rs368504231	A>V	A:413	(-22.72, 2.11, -6.44)
2:10580992		Q>L	A:415	(-21.11, 1.50, -0.97)

2OO0.A | ODC1.

2OO0.A | ODC1

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Pathogenic Proximity Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:10585138	COSM246170	E>D	A:7	(-42.72, -4.72, -6.23)
2:10585130	COSM75690	D>G	A:10	(-35.70, -5.38, -11.09)
2:10583952	COSM1259840	R>W	A:154	(-34.96, 30.37, -21.79)
2:10581734	COSM1641606	M>T	A:381	(-29.37, -6.34, -33.27)
2:10581690	COSM216500	T>A	A:396	(-48.19, 1.83, -28.42)
2:10581645	COSM232932	G>R	A:411	(-21.93, -2.05, -4.51)