4FXF.B | PKM – ASTRID

4FXF.B | PKM

General Structure Information

PDB ID	4fxf
HGNC Gene Label(s)	PKM
Structure Name	structure of m2 pyruvate kinase in complex with phenylalanine
Resolution	2.55Å
Reference	AUTH H.P.MORGAN,F.J.OREILLY,M.A.WEAR,J.R.ONEILL,AUTH 2 L.A.FOTHERGILL-GILMORE,T.HUPP,M.D.WALKINSHAWTITL M2 PYRUVATE KINASE PROVIDES A MECHANISM FOR NUTRIENT SENSINGTITL 2 AND REGULATION OF CELL PROLIFERATION.REF PROC.NATL.ACAD.SCI.USA V. 110 5881 2013REFN ISSN 0027-8424PMID 23530218DOI 10.1073/PNAS.1217157110

Variant Set Distributions

ExAC Variants

Number Of Residues	506
Number Of SNVs	111
Number Of Permutations	60369
Optimal Distance Threshold	25.0
K Statistic	0.319
p-value	0.073

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
15:72511344		R>H	B:32	(8.25, 14.20, 86.84)
15:72511345	COSM4056671 COSM4056670 COSM4056672	R>C	B:32	(8.25, 14.20, 86.84)
15:72511342		L>M	B:33	(12.34, 13.95, 81.30)
15:72511300		I>V	B:47	(35.65, 14.32, 75.52)
15:72509829	rs147939689	R>Q	B:56	(49.41, 16.59, 63.08)
15:72509823	rs201533100	V>A	B:58	(48.75, 24.15, 67.25)
15:72509824	rs569328016	V>M	B:58	(48.75, 24.15, 67.25)
15:72509818		T>S	B:60	(42.88, 22.61, 65.52)
15:72509803		I>V	B:65	(41.50, 22.24, 74.61)
15:72509800		K>E	B:66	(38.59, 26.63, 73.51)
15:72509790		M>K	B:69	(40.29, 17.74, 74.11)
15:72509781		A>V	B:72	(44.75, 12.53, 73.23)
15:72509757		T>I	B:80	(55.29, 6.83, 61.89)
15:72509753		H>Q	B:81	(57.35, 5.82, 66.21)
15:72502818	rs142392595	Y>C	B:83	(52.03, 11.59, 62.05)
15:72502812	COSM1374397 COSM1374398	A>V	B:85	(55.95, 12.82, 68.05)
15:72502792		R>C	B:92	(52.94, 17.57, 75.30)
15:72502788		T>I	B:93	(52.23, 23.39, 72.17)
15:72502776		S>N	B:97	(48.74, 27.85, 75.67)
15:72502777		S>G	B:97	(48.74, 27.85, 75.67)
15:72502761		P>R	B:102	(46.85, 28.28, 86.89)
15:72502758		I>S	B:103	(42.76, 29.43, 88.07)
15:72502756		L>F	B:104	(41.26, 29.13, 83.76)
15:72502744		V>I	B:108	(45.45, 17.46, 78.07)
15:72502723		K>E	B:115	(49.67, -2.00, 66.35)
15:72502200		S>C	B:127	(49.16, 7.85, 51.17)
15:72502190	rs371750431	A>V	B:130	(44.60, 7.80, 50.15)
15:72502182	rs576481593	E>Q	B:133	(35.64, 4.51, 45.60)
15:72502170		G>R	B:137	(31.60, -6.97, 41.57)
15:72502164		T>A	B:139	(38.03, -8.24, 40.95)
15:72502151		T>M	B:143	(49.16, -9.57, 47.88)
15:72502148	COSM4056662 COSM4056661 COSM4056663	L>P	B:144	(51.22, -12.00, 50.85)
15:72502139		A>V	B:147	(56.05, -4.60, 46.68)
15:72502140	rs146173648	A>T	B:147	(56.05, -4.60, 46.68)
15:72502136		Y>C	B:148	(52.34, -5.11, 45.32)
15:72502134	rs112954819	M>V	B:149	(53.85, -2.38, 51.85)
15:72502128		K>E	B:151	(52.07, 0.22, 45.03)
15:72502125	rs368549979	C>G	B:152	(47.48, -0.35, 47.69)
15:72502122		D>N	B:153	(45.04, -0.46, 44.04)
15:72502115	rs61753428	N>S	B:155	(43.00, -3.85, 41.14)
15:72502113		I>L	B:156	(46.57, -4.57, 44.12)
15:72502103		L>P	B:159	(47.29, -8.07, 54.06)
15:72502095		K>E	B:162	(53.03, -13.43, 56.37)
15:72502018		Q>H	B:187	(40.37, -17.93, 42.61)
15:72501227	rs200525707	D>N	B:191	(51.28, -16.01, 47.60)
15:72501214		T>M	B:195	(38.38, -11.26, 46.09)
15:72501200	rs11558354	G>S	B:200	(30.74, -0.86, 48.44)
15:72501193	rs141732747	S>F	B:202	(35.62, 4.03, 50.76)
15:72501163		P>R	B:212	(34.84, -13.88, 61.67)
15:72501157	rs182730190	A>V	B:214	(38.98, -17.64, 62.42)
15:72501143	rs552662710	P>S	B:219	(51.02, -12.51, 69.28)
15:72501133	rs143294717	S>L	B:222	(54.04, -7.64, 68.97)
15:72501118		Q>R	B:227	(59.08, -1.26, 68.54)
15:72501119		Q>K	B:227	(59.08, -1.26, 68.54)
15:72501098	rs149108298	E>K	B:234	(60.80, 7.05, 75.05)
15:72501094	rs149152236	Q>L	B:235	(57.17, 10.58, 74.06)
15:72501092	rs548240358	D>N	B:236	(55.45, 11.11, 79.61)
15:72501082		M>T	B:239	(46.63, 6.66, 78.99)
15:72501083		M>L	B:239	(46.63, 6.66, 78.99)
15:72501073	COSM1287178 COSM1287179	A>V	B:242	(45.05, -2.27, 74.75)
15:72501061		R>H	B:246	(43.18, -12.27, 73.35)
15:72501059	rs369499375	K>E	B:247	(43.83, -13.71, 77.54)
15:72501044		H>N	B:252	(49.05, -9.85, 83.66)
15:72501038		V>L	B:254	(51.15, -4.88, 78.60)
15:72501030		K>N	B:256	(55.55, -8.34, 82.71)
15:72501001	rs145060432	K>R	B:266	(46.74, 4.09, 84.17)
15:72500998	rs376321558	I>T	B:267	(46.72, -0.70, 81.27)
15:72500980		N>T	B:273	(37.25, -10.25, 70.77)
15:72500966		R>W	B:278	(34.67, -16.54, 77.05)
15:72499612		D>E	B:281	(35.11, -10.81, 84.93)
15:72499607		I>N	B:283	(40.23, -8.62, 81.28)
15:72499578		A>S	B:293	(35.63, -1.49, 70.99)
15:72499554		I>V	B:301	(30.18, -9.79, 68.04)
15:72499551		P>A	B:302	(26.79, -10.40, 66.48)
15:72499508		R>Q	B:316	(30.34, -6.57, 84.95)
15:72499509	rs147956260	R>W	B:316	(30.34, -6.57, 84.95)
15:72499502	rs149836418	N>S	B:318	(30.23, 1.65, 87.06)
15:72499485		V>I	B:324	(34.24, 2.75, 81.11)
15:72499193	rs2959910 CM097299	R>H	B:339	(22.87, 17.77, 62.28)
15:72499190		P>H	B:340	(24.25, 14.77, 64.14)
15:72499187		T>I	B:341	(22.29, 11.11, 63.04)
15:72499172		S>N	B:346	(20.79, 8.42, 71.13)
15:72499140		D>N	B:357	(33.64, 7.17, 82.97)
15:72499134		I>V	B:359	(32.60, 10.03, 75.31)
15:72499100		Y>C	B:370	(32.44, 19.28, 59.54)
15:72499086		V>M	B:375	(34.05, 17.99, 70.40)
15:72499082	COSM1147602 COSM701317	R>H	B:376	(32.01, 22.68, 69.34)
15:72499083		R>C	B:376	(32.01, 22.68, 69.34)
15:72495523	rs199599246	R>C	B:383	(25.84, 20.20, 79.70)
15:72495495	rs191520472	R>H	B:392	(18.69, 9.79, 93.82)
15:72495496	rs199853847	R>C	B:392	(18.69, 9.79, 93.82)
15:72495474		V>A	B:399	(24.98, 2.76, 99.66)
15:72495465	rs546090006	S>L	B:402	(29.43, -1.45, 98.48)
15:72495463		S>G	B:403	(32.13, -3.44, 99.56)
15:72495449	rs374523679	D>E	B:407	(40.26, 2.26, 103.46)
15:72495443		M>I	B:409	(40.26, 6.66, 102.04)
15:72495444		M>R	B:409	(40.26, 6.66, 102.04)
15:72495421	COSM555813	V>M	B:417	(29.06, 11.38, 98.43)
15:72495399		L>S	B:424	(23.35, 20.67, 97.77)
15:72495375	rs201350316 COSM1726964	T>M	B:432	(45.30, 13.97, 95.31)
15:72492979		A>V	B:442	(34.01, 8.90, 91.57)
15:72492970		R>H	B:445	(29.35, 8.04, 89.62)
15:72492940	COSM1152880 COSM964582	R>Q	B:455	(51.68, 20.48, 94.35)
15:72492922	rs141505399	R>H	B:461	(48.27, 14.46, 82.56)
15:72492923		R>C	B:461	(48.27, 14.46, 82.56)
15:72492917	rs542685905	A>S	B:463	(41.57, 12.13, 86.09)
15:72492911	COSM1301398 COSM1301399	L>M	B:465	(39.98, 7.99, 82.74)
15:72492905	COSM4056648 COSM4056647 COSM4056649	R>C	B:467	(31.22, 10.18, 85.21)
15:72492881		K>E	B:475	(52.47, 25.07, 88.98)
15:72492863		A>T	B:481	(53.60, 24.79, 106.97)
15:72492847		V>A	B:486	(46.51, 22.10, 103.19)
15:72492848		V>M	B:486	(46.51, 22.10, 103.19)
15:72492842		L>F	B:488	(47.60, 27.49, 99.55)
15:72492839		R>W	B:489	(47.07, 21.98, 98.63)
15:72492827		A>T	B:493	(40.01, 25.20, 94.71)
15:72492820		N>I	B:495	(40.22, 30.66, 93.64)
15:72492088	COSM3816687 COSM3816686 COSM3816688	R>Q	B:500	(36.51, 26.59, 86.11)
15:72492085		G>D	B:501	(30.90, 28.26, 88.34)
15:72492059		I>L	B:510	(32.65, 18.86, 100.86)
15:72492040		R>H	B:516	(51.41, 11.38, 107.03)
15:72492041	COSM1588081 COSM964581	R>C	B:516	(51.41, 11.38, 107.03)
15:72492014		M>V	B:525	(34.46, 15.54, 106.02)
15:72492010		R>H	B:526	(37.17, 20.42, 106.41)
15:72491995	rs371099168	P>L	B:531	(35.80, 32.34, 100.59)