General Structure Information
| PDB ID | 1nd5 |
| HGNC Gene Label(s) | ACPP |
| Structure Name | crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design |
| Resolution | 2.9Å |
| Reference | AUTH E.ORTLUND,M.W.LACOUNT,L.LEBIODATITL CRYSTAL STRUCTURES OF HUMAN PROSTATIC ACID PHOSPHATASE INTITL 2 COMPLEX WITH A PHOSPHATE ION ANDTITL 3 ALPHA-BENZYLAMINOBENZYLPHOSPHONIC ACID UPDATE THETITL 4 MECHANISTIC PICTURE AND OFFER NEW INSIGHTS INTO INHIBITORTITL 5 DESIGNREF BIOCHEMISTRY V. 42 383 2003REFN ISSN 0006-2960PMID 12525165DOI 10.1021/BI0265067 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 342 |
| Number Of SNVs | 96 |
| Number Of Permutations | 45114 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.061 |
| p-value | 0.064 |
COSMIC
| Number Of Residues | 342 |
| Number Of SNVs | 11 |
| Number Of Permutations | 3775 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.364 |
| p-value | 0.346 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 96 |
| Number Of COSMIC SNVs | 10 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | -0.032 |
| p-value | 0.787 |