General Structure Information
| PDB ID | 2vo1 |
| HGNC Gene Label(s) | CTPS1 |
| Structure Name | crystal structure of the synthetase domain of human ctp synthetase |
| Resolution | 2.8Å |
| Reference | AUTH P.KURSULA,S.FLODIN,M.EHN,M.HAMMARSTROM,H.SCHULER,P.NORDLUND,AUTH 2 P.STENMARKTITL STRUCTURE OF THE SYNTHETASE DOMAIN OF HUMAN CTP SYNTHETASE,TITL 2 A TARGET FOR ANTICANCER THERAPY.REF ACTA CRYSTALLOGR.,SECT.F V. 62 613 2006REFN ISSN 1744-3091PMID 16820675DOI 10.1107/S1744309106018136 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 233 |
| Number Of SNVs | 21 |
| Number Of Permutations | 10290 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.019 |
| p-value | 0.806 |
COSMIC
| Number Of Residues | 233 |
| Number Of SNVs | 3 |
| Number Of Permutations | 27 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.667 |
| p-value | 0.296 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 21 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.667 |
| p-value | 0.211 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
