General Structure Information
| PDB ID | 1a12 |
| HGNC Gene Label(s) | RCC1 |
| Structure Name | regulator of chromosome condensation (rcc1) of human |
| Resolution | 1.7Å |
| Reference | AUTH L.RENAULT,N.NASSAR,I.VETTER,J.BECKER,C.KLEBE,AUTH 2 M.ROTH,A.WITTINGHOFERTITL THE 1.7 A CRYSTAL STRUCTURE OF THE REGULATOR OFTITL 2 CHROMOSOME CONDENSATION (RCC1) REVEALS ATITL 3 SEVEN-BLADED PROPELLER.REF NATURE V. 392 97 1998REFN ISSN 0028-0836PMID 9510255DOI 10.1038/32204 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 401 |
| Number Of SNVs | 87 |
| Number Of Permutations | 15990 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.127 |
| p-value | 0.018 |
COSMIC
| Number Of Residues | 401 |
| Number Of SNVs | 3 |
| Number Of Permutations | 27 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 87 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 31.0 |
| K Statistic | -0.313 |
| p-value | 0.68 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
