General Structure Information
| PDB ID | 1itb |
| HGNC Gene Label(s) | IL1R1 |
| Structure Name | type-1 interleukin-1 receptor complexed with interleukin-1 beta |
| Resolution | 2.5Å |
| Reference | AUTH G.P.VIGERS,L.J.ANDERSON,P.CAFFES,B.J.BRANDHUBERTITL CRYSTAL STRUCTURE OF THE TYPE-I INTERLEUKIN-1TITL 2 RECEPTOR COMPLEXED WITH INTERLEUKIN-1BETA.REF NATURE V. 386 190 1997REFN ISSN 0028-0836PMID 9062193DOI 10.1038/386190A0 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 310 |
| Number Of SNVs | 63 |
| Number Of Permutations | 21806 |
| Optimal Distance Threshold | 32.0 |
| K Statistic | 0.476 |
| p-value | 0.363 |
COSMIC
| Number Of Residues | 310 |
| Number Of SNVs | 8 |
| Number Of Permutations | 7858 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.75 |
| p-value | 0.007 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 63 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.362 |
| p-value | 0.097 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
