General Structure Information
| PDB ID | 3gd7 |
| HGNC Gene Label(s) | CFTR |
| Structure Name | crystal structure of human nbd2 complexed with n6- phenylethyl-atp (p-atp) |
| Resolution | 2.7Å |
| Reference | AUTH S.ATWELL,S.ANTONYSAMY,W.B.GUGGINO,K.CONNERS,AUTH 2 S.EMTAGE,T.GHEYI,J.F.HUNT,H.A.LEWIS,F.LU,AUTH 3 J.M.SAUDER,P.C.WEBER,D.WETMORE,X.ZHAOTITL CRYSTAL STRUCTURE OF HUMAN NBD2 COMPLEXED WITHTITL 2 N6-PHENYLETHYL-ATP (P-ATP)REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 233 |
| Number Of SNVs | 78 |
| Number Of Permutations | 11280 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.034 |
| p-value | 0.548 |
ClinVar
| Number Of Residues | 233 |
| Number Of SNVs | 16 |
| Number Of Permutations | 2123 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.067 |
| p-value | 0.577 |
COSMIC
| Number Of Residues | 233 |
| Number Of SNVs | 5 |
| Number Of Permutations | 468 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.1 |
| p-value | 0.655 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 78 |
| Number Of ClinVar SNVs | 12 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.024 |
| p-value | 0.278 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 78 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | -0.24 |
| p-value | 0.533 |