General Structure Information
| PDB ID | 3ky9 |
| HGNC Gene Label(s) | VAV1 |
| Structure Name | autoinhibited vav1 |
| Resolution | 2.73Å |
| Reference | AUTH B.YU,I.R.MARTINS,P.LI,G.K.AMARASINGHE,J.UMETANI,AUTH 2 M.E.FERNANDEZ-ZAPICO,D.D.BILLADEAU,M.MACHIUS,D.R.TOMCHICK,AUTH 3 M.K.ROSENTITL STRUCTURAL AND ENERGETIC MECHANISMS OF COOPERATIVETITL 2 AUTOINHIBITION AND ACTIVATION OF VAV1REF CELL(CAMBRIDGE,MASS.) V. 140 246 2010REFN ISSN 0092-8674PMID 20141838DOI 10.1016/J.CELL.2009.12.033 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 540 |
| Number Of SNVs | 82 |
| Number Of Permutations | 15617 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.245 |
| p-value | 0.031 |
COSMIC
| Number Of Residues | 540 |
| Number Of SNVs | 10 |
| Number Of Permutations | 3388 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.022 |
| p-value | 0.966 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 82 |
| Number Of COSMIC SNVs | 16 |
| Optimal Distance Threshold | 35.0 |
| K Statistic | 0.109 |
| p-value | 0.278 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
