General Structure Information
| PDB ID | 2qc8 |
| HGNC Gene Label(s) | GLUL |
| Structure Name | crystal structure of human glutamine synthetase in complex with adp and methionine sulfoximine phosphate |
| Resolution | 2.6Å |
| Reference | AUTH W.W.KRAJEWSKI,R.COLLINS,L.HOLMBERG-SCHIAVONE,T.A.JONES,AUTH 2 T.KARLBERG,S.L.MOWBRAYTITL CRYSTAL STRUCTURES OF MAMMALIAN GLUTAMINE SYNTHETASESTITL 2 ILLUSTRATE SUBSTRATE-INDUCED CONFORMATIONAL CHANGES ANDTITL 3 PROVIDE OPPORTUNITIES FOR DRUG AND HERBICIDE DESIGN.REF J.MOL.BIOL. V. 375 217 2008REFN ISSN 0022-2836PMID 18005987DOI 10.1016/J.JMB.2007.10.029 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 356 |
| Number Of SNVs | 83 |
| Number Of Permutations | 14625 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.057 |
| p-value | 0.324 |
COSMIC
| Number Of Residues | 356 |
| Number Of SNVs | 5 |
| Number Of Permutations | 579 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.4 |
| p-value | 0.15 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 83 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | -0.302 |
| p-value | 1.0 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
