General Structure Information
| PDB ID | 3ii5 |
| HGNC Gene Label(s) | BRAF |
| Structure Name | the complex of wild-type b-raf with pyrazolo pyrimidine inhibitor |
| Resolution | 2.79Å |
| Reference | AUTH D.M.BERGER,N.TORRES,M.DUTIA,D.POWELL,G.CISZEWSKI,AUTH 2 A.GOPALSAMY,J.I.LEVIN,K.H.KIM,W.XU,J.WILHELM,Y.HU,AUTH 3 K.COLLINS,L.FELDBERG,S.KIM,E.FROMMER,AUTH 4 D.WOJCIECHOWICZ,R.MALLONTITL NON-HINGE-BINDING PYRAZOLO[1,5-A]PYRIMIDINES ASTITL 2 POTENT B-RAF KINASE INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 19 6519 2009REFN ISSN 0960-894XPMID 19864136DOI 10.1016/J.BMCL.2009.10.049 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 262 |
| Number Of SNVs | 24 |
| Number Of Permutations | 3189 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.145 |
| p-value | 0.177 |
ClinVar
| Number Of Residues | 262 |
| Number Of SNVs | 32 |
| Number Of Permutations | 4303 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.155 |
| p-value | 0.0 |
COSMIC
| Number Of Residues | 262 |
| Number Of SNVs | 33 |
| Number Of Permutations | 9056 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.133 |
| p-value | 0.0 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 24 |
| Number Of ClinVar SNVs | 30 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.275 |
| p-value | 0.004 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 24 |
| Number Of COSMIC SNVs | 17 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.348 |
| p-value | 0.012 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
