General Structure Information
| PDB ID | 1op8 |
| HGNC Gene Label(s) | GZMA |
| Structure Name | crystal structure of human granzyme a |
| Resolution | 2.5Å |
| Reference | AUTH C.HINK-SCHAUER,E.ESTEBANEZ-PERPINA,F.KURSCHUS,AUTH 2 W.BODE,D.JENNETITL CRYSTAL STRUCTURE OF THE APOPTOSIS-INDUCING HUMANTITL 2 GRANZYME A DIMERREF NAT.STRUCT.BIOL. V. 10 535 2003REFN ISSN 1072-8368PMID 12819770DOI 10.1038/NSB945 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 225 |
| Number Of SNVs | 66 |
| Number Of Permutations | 21293 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.065 |
| p-value | 0.969 |
COSMIC
| Number Of Residues | 225 |
| Number Of SNVs | 8 |
| Number Of Permutations | 2681 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.071 |
| p-value | 0.202 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 66 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.28 |
| p-value | 0.383 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
