General Structure Information
| PDB ID | 3iw4 |
| HGNC Gene Label(s) | PRKCA |
| Structure Name | crystal structure of pkc alpha in complex with nvp-aeb071 |
| Resolution | 2.8Å |
| Reference | AUTH J.WAGNER,P.VON MATT,R.SEDRANI,R.ALBERT,N.COOKE,C.EHRHARDT,AUTH 2 M.GEISER,G.RUMMEL,W.STARK,A.STRAUSS,S.W.COWAN-JACOB,AUTH 3 C.BEERLI,G.WECKBECKER,J.P.EVENOU,G.ZENKE,S.COTTENSTITL DISCOVERY OFTITL 2 3-(1H-INDOL-3-YL)-4-[2-(4-METHYLPIPERAZIN-1-YL)QUINAZOLIN-4-TITL 3 YL]PYRROLE-2,5-DIONE (AEB071), A POTENT AND SELECTIVETITL 4 INHIBITOR OF PROTEIN KINASE C ISOTYPESREF J.MED.CHEM. V. 52 6193 2009REFN ISSN 0022-2623PMID 19827831DOI 10.1021/JM901108B |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 332 |
| Number Of SNVs | 57 |
| Number Of Permutations | 31395 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.201 |
| p-value | 0.409 |
COSMIC
| Number Of Residues | 332 |
| Number Of SNVs | 8 |
| Number Of Permutations | 1611 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.321 |
| p-value | 0.801 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 57 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.121 |
| p-value | 0.469 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
