General Structure Information
| PDB ID | 3dyd |
| HGNC Gene Label(s) | TAT |
| Structure Name | human tyrosine aminotransferase |
| Resolution | 2.3Å |
| Reference | AUTH T.KARLBERG,M.MOCHE,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KOTENYOVA,L.LEHTIO,M.E.NILSSON,P.NORDLUND,T.NYMAN,AUTH 5 K.OLESEN,C.PERSSON,J.SAGEMARK,A.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WIKSTROM,M.WISNIEWSKA,AUTH 7 H.SCHULER,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL HUMAN TYROSINE AMINOTRANSFERASEREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 388 |
| Number Of SNVs | 83 |
| Number Of Permutations | 15265 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.237 |
| p-value | 0.071 |
COSMIC
| Number Of Residues | 388 |
| Number Of SNVs | 8 |
| Number Of Permutations | 1550 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.036 |
| p-value | 0.061 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 83 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | -0.165 |
| p-value | 0.113 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
