General Structure Information
| PDB ID | 2d0u |
| HGNC Gene Label(s) | IDO1 |
| Structure Name | crystal structure of cyanide bound form of human indoleamine 2,3-dioxygenase |
| Resolution | 3.4Å |
| Reference | AUTH H.SUGIMOTO,S.ODA,T.OTSUKI,T.HINO,T.YOSHIDA,Y.SHIROTITL CRYSTAL STRUCTURE OF HUMAN INDOLEAMINETITL 2 2,3-DIOXYGENASE: CATALYTIC MECHANISM OF O2TITL 3 INCORPORATION BY A HEME-CONTAINING DIOXYGENASE.REF PROC.NATL.ACAD.SCI.USA V. 103 2611 2006REFN ISSN 0027-8424PMID 16477023DOI 10.1073/PNAS.0508996103 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 374 |
| Number Of SNVs | 87 |
| Number Of Permutations | 15294 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.025 |
| p-value | 0.172 |
COSMIC
| Number Of Residues | 374 |
| Number Of SNVs | 8 |
| Number Of Permutations | 6116 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.357 |
| p-value | 0.227 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 87 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.284 |
| p-value | 0.078 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
