General Structure Information
| PDB ID | 4j15 |
| HGNC Gene Label(s) | DARS |
| Structure Name | crystal structure of human cytosolic aspartyl-trna synthetase, a component of multi-trna synthetase complex |
| Resolution | 2.24Å |
| Reference | AUTH K.R.KIM,S.H.PARK,H.S.KIM,K.H.RHEE,B.-G.KIM,D.G.KIM,M.S.PARK,AUTH 2 H.-J.KIM,S.KIM,B.W.HANTITL CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC ASPARTYL-TRNATITL 2 SYNTHETASE, A COMPONENT OF MULTI-TRNA SYNTHETASE COMPLEXREF PROTEINS V. 81 1840 2013REFN ISSN 0887-3585PMID 23609930DOI 10.1002/PROT.24306 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 431 |
| Number Of SNVs | 119 |
| Number Of Permutations | 31605 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.047 |
| p-value | 0.479 |
ClinVar
| Number Of Residues | 431 |
| Number Of SNVs | 3 |
| Number Of Permutations | 337 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.0 |
| p-value | 0.323 |
COSMIC
| Number Of Residues | 431 |
| Number Of SNVs | 5 |
| Number Of Permutations | 621 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.1 |
| p-value | 0.902 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 119 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | -0.405 |
| p-value | 0.32 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 119 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.09 |
| p-value | 0.589 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
