General Structure Information
| PDB ID | 4gdx |
| HGNC Gene Label(s) | GGT1 |
| Structure Name | crystal structure of human gamma-glutamyl transpeptidase–glutamate complex |
| Resolution | 1.67Å |
| Reference | AUTH M.B.WEST,Y.CHEN,S.WICKHAM,A.HEROUX,K.CAHILL,M.H.HANIGAN,AUTH 2 B.H.MOOERSTITL NOVEL INSIGHTS INTO EUKARYOTIC GAMMA-GLUTAMYLTRANSPEPTIDASETITL 2 1 FROM THE CRYSTAL STRUCTURE OF THE GLUTAMATE-BOUND HUMANTITL 3 ENZYME.REF J.BIOL.CHEM. V. 288 31902 2013REFN ISSN 0021-9258PMID 24047895DOI 10.1074/JBC.M113.498139 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 342 |
| Number Of SNVs | 56 |
| Number Of Permutations | 8473 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.265 |
| p-value | 0.004 |
COSMIC
| Number Of Residues | 342 |
| Number Of SNVs | 12 |
| Number Of Permutations | 3155 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.015 |
| p-value | 0.417 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 56 |
| Number Of COSMIC SNVs | 10 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | -0.103 |
| p-value | 0.09 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
