General Structure Information
| PDB ID | 3fe1 |
| HGNC Gene Label(s) | HSPA6 |
| Structure Name | crystal structure of the human 70kda heat shock protein 6 (hsp70b) atpase domain in complex with adp and inorganic phosphate |
| Resolution | 2.2Å |
| Reference | AUTH M.WISNIEWSKA,T.KARLBERG,L.LEHTIO,I.JOHANSSON,AUTH 2 T.KOTENYOVA,M.MOCHE,H.SCHUELERTITL CRYSTAL STRUCTURES OF THE ATPASE DOMAINS OF FOURTITL 2 HUMAN HSP70 ISOFORMS: HSPA1L/HSP70-HOM,TITL 3 HSPA2/HSP70-2, HSPA6/HSP70B, AND HSPA5/BIP/GRP78REF PLOS ONE V. 5 E8625 2010REFN ESSN 1932-6203PMID 20072699DOI 10.1371/JOURNAL.PONE.0008625 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 380 |
| Number Of SNVs | 62 |
| Number Of Permutations | 11836 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.06 |
| p-value | 0.002 |
COSMIC
| Number Of Residues | 380 |
| Number Of SNVs | 8 |
| Number Of Permutations | 4752 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.214 |
| p-value | 0.513 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 62 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | -0.25 |
| p-value | 0.391 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
