General Structure Information
| PDB ID | 2ypa |
| HGNC Gene Label(s) | TAL1 |
| Structure Name | structure of the scl:e47:lmo2:ldb1 complex bound to dna |
| Resolution | 2.8Å |
| Reference | AUTH K.EL OMARI,S.J.HOOSDALLY,K.TULADHAR,D.KARIA,E.HALL-PONSELE,AUTH 2 O.PLATONOVA,P.VYAS,R.PATIENT,C.PORCHER,E.J.MANCINITITL STRUCTURAL BASIS FOR LMO2-DRIVEN RECRUITMENT OF THETITL 2 SCL:E47BHLH HETERODIMER TO HEMATOPOIETIC-SPECIFICTITL 3 TRANSCRIPTIONAL TARGETS.REF CELL REP. V. 4 135 2013REFN ISSN 2211-1247PMID 23831025DOI 10.1016/J.CELREP.2013.06.008 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 67 |
| Number Of SNVs | 8 |
| Number Of Permutations | 6659 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.214 |
| p-value | 0.744 |
COSMIC
| Number Of Residues | 67 |
| Number Of SNVs | 3 |
| Number Of Permutations | 7 |
| Optimal Distance Threshold | 31.0 |
| K Statistic | 0.333 |
| p-value | 0.633 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 8 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | -0.393 |
| p-value | 0.245 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
