General Structure Information
| PDB ID | 3bu6 |
| HGNC Gene Label(s) | INSR |
| Structure Name | crystal structure of the insulin receptor kinase in complex with irs2 krlb phosphopeptide |
| Resolution | 1.95Å |
| Reference | AUTH J.WU,Y.D.TSENG,C.F.XU,T.A.NEUBERT,M.F.WHITE,AUTH 2 S.R.HUBBARDTITL STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF THETITL 2 KRLB REGION IN INSULIN RECEPTOR SUBSTRATE-2.REF NAT.STRUCT.MOL.BIOL. V. 15 251 2008REFN ISSN 1545-9993PMID 18278056DOI 10.1038/NSMB.1388 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 294 |
| Number Of SNVs | 50 |
| Number Of Permutations | 6446 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.033 |
| p-value | 0.056 |
ClinVar
| Number Of Residues | 294 |
| Number Of SNVs | 8 |
| Number Of Permutations | 991 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.393 |
| p-value | 0.133 |
COSMIC
| Number Of Residues | 294 |
| Number Of SNVs | 3 |
| Number Of Permutations | 202 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.333 |
| p-value | 0.488 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 50 |
| Number Of ClinVar SNVs | 8 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.223 |
| p-value | 0.077 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 50 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.563 |
| p-value | 0.359 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
