General Structure Information
| PDB ID | 4ilw |
| HGNC Gene Label(s) | MMP10 |
| Structure Name | complex of matrix metalloproteinase-10 catalytic domain (mmp-10cd) with tissue inhibitor of metalloproteinases-2 (timp-2) |
| Resolution | 2.1Å |
| Reference | AUTH J.BATRA,A.S.SOARES,C.MEHNER,E.S.RADISKYTITL MATRIX METALLOPROTEINASE-10/TIMP-2 STRUCTURE AND ANALYSESTITL 2 DEFINE CONSERVED CORE INTERACTIONS AND DIVERSE EXOSITETITL 3 INTERACTIONS IN MMP/TIMP COMPLEXES.REF PLOS ONE V. 8 75836 2013REFN ESSN 1932-6203PMID 24073280DOI 10.1371/JOURNAL.PONE.0075836 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 159 |
| Number Of SNVs | 56 |
| Number Of Permutations | 2911 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.185 |
| p-value | 0.825 |
COSMIC
| Number Of Residues | 159 |
| Number Of SNVs | 3 |
| Number Of Permutations | 27 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.333 |
| p-value | 0.367 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 56 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.271 |
| p-value | 0.607 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
